森下仁丹 List of Products and Services

This document introduces an oral vaccine utilizing the Jintan seamless capsule technology as new technical information for drug development. The new oral vaccine employs a formulation that is not affected by gastric acid or digestive enzymes, maximizing the antigen presentation capability and addressing issues faced by existing oral vaccines, such as antigen inactivation and low antigen presentation ability. Additionally, the oral vaccine can be self-administered, eliminating the need for clinic visits, and it induces both systemic and mucosal immunity. It also has advantages such as being more cost-effective than conventional vaccines. [Contents] ■ Development needs for oral vaccines ■ Development of oral vaccines utilizing seamless capsule technology ■ Features of the new oral vaccine (seamless capsule) *For more details, please refer to the PDF document or feel free to contact us.

• Other contract manufacturing

Morishita Jintan's seamless capsule technology can encapsulate various substances such as powders, liquids, and microorganisms, creating a shape that is literally seamless and close to a perfect sphere. By encapsulating liquids and powders that are difficult to use in their original form, it is possible to transform them into a solid appearance, thereby improving measurability and portability. Substances that may oxidize when left in the air or deteriorate due to light or moisture can also have their storage stability enhanced through encapsulation. It is also possible to incorporate a release function for the contents within the capsule membrane and the multilayer structure of the capsule.

• Contract manufacturing

Morishita Jintan Co., Ltd.'s seamless capsule technology is our core technology that can encapsulate various substances such as powders, liquids, and microorganisms. The "seamless capsule" is different from soft capsules made by rotary methods; it is a capsule with no seams and a shape close to a perfect sphere. This capsule is produced using a technology uniquely established by our company based on the "liquid droplet method." By simultaneously discharging liquid coating material and contents from a concentric multi-nozzle, interfacial tension acts between the coating liquid and the content liquid, allowing the coating liquid to envelop the content liquid. We apply seamless capsules with 2-layer, 3-layer, and 4-layer structures for the encapsulation of hydrophilic liquids, lipophilic liquids, and powders (dispersions), and we have built a track record in various fields including food, supplements, cosmetics, and pharmaceuticals. 【Features】 ■ Excellent formulation accuracy ■ Adjustable particle size ranging from 0.5mm to 8mm ■ Multi-layer structure capsules capable of incorporating various functions and substances ■ Capable of encapsulating a wide variety of internal liquids ■ Capable of encapsulating microorganisms such as beneficial probiotics (as dispersions) *For more details, please refer to our catalog or feel free to contact us.

• Contract manufacturing