インデナジャパン List of Products and Services

- Italy has a suitable climate and land for growing various varieties of kale and broccoli. - Kale seeds have been found to be a rich source of sulforaphane glucosinolate as a result of screening various kales and broccolis. - High content of sulforaphane glucosinolate > 17% - Water-soluble - Glucoraphanin is a substance already known to be beneficial for liver function and skin health. - Complies with functional food labeling (PRISMA2020).

• Food/beverage functional materials

Hydroxycinnamic acid derivatives (as rosmarinic acid) 10.0% or more

• Food ingredients (powder)

Total Apigenin 1.2% or more HPLC

• Food ingredients (powder)

It is famous in Europe and the United States as an adaptogen material. Adaptogens refer to specific foods or supplements that help the body cope with stress. *Made in Italy*

• Food/beverage functional materials

【Features】 ■ Total gingerol and total shogaol > 25% ■ CO2 extraction ■ Strong flavor and aroma characteristic of ginger ■ Immediate effects on the body (sweating and increased body temperature) ■ Ingredients suitable for functional food labeling (Notification number: I867) This product contains ginger-derived polyphenols (6-gingerol, 6-shogaol). It has been reported that this component helps maintain the temperature of peripheral areas (fingertips, wrists, and palms) for those who are concerned about feeling cold in chilly environments. *For more details, please contact us.

• Food/beverage functional materials

- Evidence for the prevention of recurrent urinary tract infections - Recommended daily amount: 120mg - Inhibitory activity against Candida and E. coli - Effective with a smaller amount of PAC (proanthocyanidins) compared to conventional cranberry extract

• Food ingredients (powder)

- Analgesic effect at a low dose (50mg/day) - Clinical trials ongoing with subjects suffering from knee joint pain - Acmella is cultivated on the island of Sardinia (Italy) - Standardized total alkylamide content at 2.5 - 3.5% - Extract powder with a sharp spicy flavor

• Food ingredients (powder)

Indena will hold a seminar at the "Food Development Expo 2022" taking place at Tokyo Big Sight from October 12. We will introduce a variety of high-quality plant extracts, including Mitidore, which is formulated with Acmella extract, Kersefit, which has a track record of functional labeling acceptance, and lemon balm extract. 【Seminar Details】 ▼ October 12 (Wed) 12:00 - 12:25 / PJ Venue (West Hall 2) "New Material for Pain Care: Italian Dutch Senna Extract (Mitidore)" https://ls.ipros.jp/product/detail/2000742816 ▼ October 13 (Thu) 12:00 - 12:25 / PJ Venue (West Hall 2) "Versatile Material - Latest Insights on High Absorption Quercetin Kersefit" https://ls.ipros.jp/product/detail/2000529072 ▼ October 14 (Fri) 11:30 - 11:55 / PK Venue (West Hall 2) "New Material for Stress Response (Sleep, Mood): Lemon Balm Extract (Relissa)" https://ls.ipros.jp/product/detail/2000742818

• Food/beverage functional materials

【Features】 ■ Bitter components of food ■ Quassin + Neoquassin standard: 53-57% *For more details, please contact us.

• Food/beverage functional materials
• Fragrances

【Features】 ■ Industry's lowest caffeine-free content (below 0.1%) ■ Specifications Total polyphenols (7 types): 60% or more (calculated as EGCG) EGCG: 40% or more *For more details, please contact us.

• Food/beverage functional materials
• Food ingredients (powder)

【Features】 ■ Standardized saponin at approximately 10% ■ Pharmaceutical product for venous insufficiency and hemorrhoids in Europe *For more details, please contact us.

• Food/beverage functional materials

【Features】 ■ Standardized with 0.25% sesquiterpenic acid ■ Raw material for pharmaceuticals in Europe and the United States *For more details, please contact us.

• Food/beverage functional materials

【Features】 ■ Pharmaceutical raw material in Europe and the United States ■ Made in Italy *For more details, please contact us.

• Food/beverage functional materials

【Features】 ■ Pharmaceutical material in Europe and the United States ■ Standardized high concentration of proanthocyanidins *For more details, please contact us.

• Food/beverage functional materials

【Features】 ■ Korean cosmetics CICA is currently trending in Japan ■ A well-known skin-beautifying ingredient in cosmetics ■ Promotes collagen production ■ Completed human clinical trials *For more details, please contact us.

• Food/beverage functional materials

【Features】 ■ Hydroxycinnamic acid standard: 17-23% (HPLC method) ■ Contains phospholipids (lecithin) to optimize bioabsorption *For more details, please contact us.

• Food/beverage functional materials

【Features】 ■ Japan's first introduction of a mixed formulation of Acmella extract and supercritical ginger extract ■ A completely new knee joint formulation that excels in sensory experience and rapid effectiveness ■ Clinical trials completed (for knee pain relief) ■ Acts on the endocannabinoid system similar to CBD ■ Patent pending *For more details, please contact us.

• Food/beverage functional materials

【Features】 ■Patented anti-dandruff and hair growth material ■Human clinical trials conducted on hair *For more details, please contact us.

• Food/beverage functional materials

【Features】 ■ High content of plant-based omega-3 fatty acids ■ Supercritical CO2 extraction method *For more details, please contact us.

• Food/beverage functional materials

【Features】 ■ Two products: food and additives ■ Proanthocyanidin standard is among the best in the industry *For more details, please contact us.

• Food/beverage functional materials

【Features】 ■ Standardized with approximately 10% ginsenosides (ginseng saponins) ■ Manufactured in a factory with pharmaceutical-grade management (Italy) ■ Continuously adopted by major manufacturers' products *For more details, please contact us.

• Food/beverage functional materials

【Features】 ■ Manufactured in France ■ Complies with functional food labeling (PRISMA2020) ■ Ginkgolide content below 1ppm ■ Increasing attention on nootropics (smart drugs) *For more details, please contact us.

• Food/beverage functional materials

【Features】 ■ Supercritical CO2 extraction method ■ Standardized fatty acids and plant sterols ■ 5α-reductase inhibition ■ Used in combination with saw palmetto *For more details, please contact us.

• Food/beverage functional materials

【Hair Growth, Hair & Nails】 Total Fatty Acids 3.0% or more *Made in France Clinical data available.

• Food/beverage functional materials

【Cholesterol, blood sugar levels, visceral fat】 Total flavanone 14% Improved absorption rate with Indena's proprietary technology, Phytosome. Conducted in-house human clinical trials. *Made in Italy

• Food/beverage functional materials

"Bean Block" is a patented refined extract of kidney beans. It is derived from a unique variety grown in Italy and is standardized with two groups of proteins through three different approaches. This product's efficacy is supported by abundant preclinical data. 【Features】 ■ Patented refined extract of kidney beans ■ Derived from a unique variety grown in Italy ■ Applicable to various formulations ■ Efficacy supported by abundant preclinical data *For more details, please refer to the PDF document or feel free to contact us.

• Food ingredients (liquid)

"Milto Select" is a unique bilberry extract backed by technology. It uses fresh bilberries (Vaccinium myrtillus L) harvested during the maturation period from July to September. Extensive clinical and pharmacological data support the effectiveness of this product. 【Features】 ■ Unique bilberry extract ■ Technology-backed standardized extract ■ Extensive clinical and pharmacological data support effectiveness ■ Contains 36% anthocyanins ■ Uses fresh bilberries harvested during the maturation period from July to September ■ Complies with functional food labeling (PRISMA2020) *For more details, please refer to the PDF materials or feel free to contact us.

• Food/beverage functional materials

"Sabal Select" is an extract derived from a unique CO2 extraction of saw palmetto fruit. It has been specifically developed for the improvement of various symptoms associated with benign prostatic hyperplasia and is manufactured through a special CO2 extraction process under strict GMP standards. Additionally, it has a clear chemical profile verified by certified gas-liquid chromatography analysis. 【Features】 ■ Unique CO2 saw palmetto fruit extract ■ Specifically developed for the improvement of various symptoms associated with benign prostatic hyperplasia ■ Effectiveness supported by clinical and pharmacological data ■ A product designed with safety in mind, free from side effects ■ Manufactured under strict GMP standards *For more details, please refer to the PDF document or feel free to contact us.

• Food ingredients (liquid)

"Meriba" is a patented high-absorption curcumin formulation. [Features] ■ Curcumin with high bioavailability ■ Patented high-absorption curcumin formulation ■ Clinical trials conducted in humans *For more details, please refer to the PDF document or feel free to contact us.

• Food ingredients (powder)

"Kersefit" is a high-absorption type of quercetin derived from the Enju plant, currently under patent application. Thanks to Indena's unique phytosome technology, its bioavailability has been significantly improved by about 20 times, making it a highly regarded quercetin material that supports overall health. It has been adopted in over 50 products worldwide, with more than 10 products already utilizing it in Japan, and its track record is gradually increasing. The mechanisms of action of quercetin can be broadly divided into four categories: 1. Powerful antioxidant properties 2. Strong anti-inflammatory effects 3. Broad immune-modulating effects 4. Extensive antiviral effects Indena's clinical trials on Kersefit in humans: ◆ Accepted as a functional food for "nasal discomfort" due to pollen allergies. ◆ Anti-aging effects through the removal of senescent cells (senolytics). ◆ Histamine inhibition effects on the skin in healthy individuals. ◆ Performance enhancement effects for triathletes. ◆ Relief of symptoms in asthma patients. ◆ Treatment effects and infection prevention effects in mild COVID-19 patients (3 reports). ◆ NEW Treatment for corneal/conjunctival injuries (case report). *For more details, please refer to the PDF materials or feel free to contact us.

• Food/beverage functional materials

Our health foods and products are manufactured in approved facilities based on Hazard Analysis and Critical Control Points (HACCP). We offer a diverse lineup of dried extracts with reproducible content of characteristic ingredients. Please feel free to contact us for more information. 【Features】 ■ Manufactured based on HACCP ■ Active ingredients derived from edible and medicinal plants ■ Produced with excellent technology related to plant-derived ingredients *For more details, please refer to our catalog or feel free to contact us.

• Other food and beverage ingredients
• Food ingredients (other)
• Food/beverage functional materials

Our pharmaceutical raw materials are manufactured in facilities that have been inspected for pharmaceuticals in accordance with cGMP and are backed by CTD-DMF. Products created under excellent technology related to plant-derived ingredients include a wide range such as Ajmaline, Boldine, Colchicine USP, and Galantamine Hydrobromide. We will introduce them categorized as "isolated or semi-synthetic refined products" and "standardized, refined, or other characteristic dry extracts." 【Features】 ■ Backed by CTD-DMF ■ Manufactured in facilities that have been inspected for pharmaceuticals ■ Active ingredients derived from edible and medicinal plants *For more details, please refer to the catalog or feel free to contact us.

• Pharmaceutical materials and carriers
• Pharmaceutical Intermediates