テクノプロ　テクノプロ・R＆D社 List of Products and Services

In our contract research and experimentation in the bio-pharmaceutical field, we have gathered experts from domestic and international public research institutions and major manufacturers, achieving high quality and performance. The researchers' areas of expertise cover a wide range, including genes, cells, proteins, animal experiments, and analysis and separation, providing a rich lineup of services. Additionally, we offer "contract synthesis/material development" focused on the synthesis of organic compounds, and through multifaceted analysis and examination, including interdisciplinary technical information, we provide "consulting" to propose solutions. [Contract Services] ■ Contract research and experimentation in the bio-pharmaceutical field ■ Contract synthesis/material development ■ Consulting *For more details, please refer to the PDF document or feel free to contact us.

• Contract Analysis
• Contract Analysis
• Contract Inspection

If you have concerns such as 'There is no protocol for separation and analysis, or I want to improve it,' 'I want purified products,' or 'I want to scale up the purification process,' please leave it to us. We offer contract services for the extraction, separation, and optimization of processes for target substances. We can accommodate various separation methods, including chromatography and membrane separation, for both analysis and fractionation purposes. [Flow of Contract Testing and Experimental Items] 1. Consultation/Request 2. Screening and optimization of pretreatment methods 3. Screening and optimization of separation and analysis methods 4. Protocol development 5. Separation of purified products/Analysis of samples 6. Scale-up considerations/Routine analysis *For more details, please refer to the PDF document or feel free to contact us.

• Contract Analysis
• Contract Analysis
• Contract Inspection

If you are unsure how to conduct cell tests according to your development objectives, or if you want to obtain accurate test data but lack the necessary equipment or experienced cell culture personnel, please leave it to us. We will evaluate various cell functions using cultured cells. We can assess using a variety of methods in the fields of 'cells and genes,' 'proteins,' and 'drug discovery screening.' Our evaluations focusing on the effects of test substances can include various assessments related to skin and beauty using normal human skin cultured cells. 【Flow of Contracted Testing and Experimental Items】 1. Hearing 2. Proposal of Testing Methods 3. Securing Cells and 3D Skin Models 4. Conducting Preliminary Tests 5. Conducting Main Tests and Preparing Test Reports *For more details, please refer to the PDF document or feel free to contact us.

• Contract Analysis
• Contract Analysis
• Contract Inspection

If you have concerns such as 'I would like to create model animals for conducting animal tests,' 'I want to evaluate drug efficacy in animal tests but don't know how,' or 'I have a protocol for animal tests, but there is no one to undertake it,' please leave it to us. We accept evaluations using animal experiments with mice and rats for various drugs. We can perform analyses in collaboration with 'cell and gene,' 'protein,' and 'separation and analysis.' [Flow of Contracted Tests and Experimental Items] 1. Hearing and Meeting 2. Preparation of Proposal and Quotation 3. Implementation of Animal Tests 4. Analysis 5. Submission of Report *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Analysis
• Contract Analysis
• Contract Inspection

If you have concerns such as 'There is no kit to quantify the target molecule,' 'I want to build a new assay system, but there is no time and no personnel,' or 'I want an evaluation system for compounds or antibodies,' please leave it to us. We offer design and construction services for screening systems that can be adapted for high-throughput screening (HTS). In collaboration with 'proteins,' 'peptides,' and 'cells/genes,' we can prepare proteins, peptides, and cells for use in assays. 【Flow of Contracted Testing and Experimental Items】 1. Hearing 2. Proposal of Assay System 3. Activity Confirmation 4. Validation 5. Compound Screening *For more details, please refer to the PDF document or feel free to contact us.

• Contract Analysis
• Contract Analysis
• Contract Inspection

★Do you have any of the following concerns? - "I want to specify only the genes and cells, and have the vector design taken care of for me." - "I want to modify the expression vector into my preferred form and have it created." - "I would like to conduct experiments on cells that have no prior experience with gene introduction." If you have any of these concerns, please leave it to us! We offer services related to gene introduction and modification in various cells (animals, microorganisms), as well as diverse analyses using cells and tissues. Collaborations with other biofields for analysis are also possible. 【Flow of Contracted Testing and Experimental Items】 1. Hearing 2. Construction of expression vector 3. Introduction of expression vector into cells 4. Selection of vector-introduced cells (cell establishment) 5. Expression analysis of introduced genes in established cells *For more details, please refer to the PDF document or feel free to contact us.

• Contract Analysis
• Contract Analysis
• Contract Inspection

If you are facing issues such as "struggling with the synthesis of highly hydrophobic peptides," "needing peptides that include cyclic structures or non-natural amino acids," or "wanting to label proteins," please leave it to us. We offer peptide synthesis and functional analysis of peptides. Physiological activity evaluation can be conducted using a variety of methods in the fields of "cells and genes" and "proteins." 【Flow of Contracted Testing and Experimental Items】 1. Hearing 2. Start of peptide synthesis 3. Purification 4. Confirmation of purity and structure 5. Delivery *For more details, please refer to the PDF document or feel free to contact us.

• Contract Analysis
• Contract Analysis
• Contract Inspection

If you have concerns such as 'I need a large amount of enzymes but lack manpower,' 'The desired protein is not expressing in a soluble form,' or 'I want a mass production protocol that can be used continuously in the future,' please leave it to us. We offer contract services for protein expression and purification using various hosts, as well as diverse analyses of proteins and enzymes using biological samples. 【Flow of Contract Testing and Experimental Items】 1. Hearing 2. Construction of Expression Vector 3. Protein Expression 4. Protein Purification 5. Quantification and Characterization of Purified Protein *For more details, please refer to the PDF document or feel free to contact us.

• Contract Analysis
• Contract Analysis
• Contract Inspection

The "Consulting Services" is a service where consultants with extensive experience and a proven track record in various fields support clients in addressing their diverse challenges with rich ideas and expertise. We form a review team centered around the consultant most familiar with the requested area of concern, and through the processes of problem analysis and the collection and organization of relevant technical information, we establish specific research and development themes for solutions. Furthermore, depending on the client's needs, we can provide technical guidance during testing phases such as lab tests, reproducibility confirmation tests, and prototype tests, as well as support for contracted testing. [Features] ■ Establish specific research and development themes for solutions ■ Possible support for technical guidance during testing phases and contracted testing ■ Team formation centered around the consultant most familiar with the area of concern *For more details, please refer to the catalog or feel free to contact us.

• Technology Development
• Research and technical staffing
• Other Consulting Services

The "Organic Compound Synthesis Contract Service" provides support for research and development focused on the synthesis of organic compounds. We conduct the synthesis of known compounds for new materials, such as pharmaceuticals, pesticides, and reagents for testing research, as well as the exploration of synthetic routes for unknown compounds. We also accommodate compounds with established synthetic routes, so please feel free to consult with us. 【Features】 ■ Weekly reporting and sharing of experimental processes ■ Reporting includes negative data as well ■ Capable of synthesizing from mg scale to approximately 1 kg ■ Able to remove metals contained in electronic materials (down to below 10 ppb) ■ Upon delivery, both the compound and a business report along with analytical data will be provided *For more details, please refer to the catalog or feel free to contact us.

• Fine chemicals (compounds, derivatives, catalysts, etc.)
• Pharmaceutical Intermediates
• Other medical supplies and cosmetic manufacturing materials

In the "Bio-Medical Contract Research Services," we provide support for research and development, focusing on bio-experiment contracting. Our team consists of researchers from public research institutions and major manufacturers both domestically and internationally, ensuring high quality and performance. With a diverse group of researchers ranging from genetic engineering to animal experiments and analytical separation, we can offer customized solutions that are not available from other companies, and we also respond to detailed requests, allowing you to utilize us as your second lab. 【Features】 ■ Achieves high quality and performance ■ Customizable solutions available ■ Responsive to detailed requests ■ Contracts aimed at sharing details of the experimental process are also possible *For more details, please refer to our catalog or feel free to contact us.

• Cell-related contract
• DNA/RNA synthesis
• Gene expression analysis contract

The "Skin-Related Cell Testing" offers a comprehensive service from cell culture to various assays (cell viability, cytokine and protein production, gene expression). We also accept safety and efficacy testing using normal cells unrelated to skin (such as vascular endothelial cells, vascular smooth muscle cells, kidney, bronchus, lung, mammary gland, prostate, bladder, corneal, blood cell lineage, liver cells, etc.), so please feel free to consult with us. [Work Content Introduction] ■ Safety Testing ■ Whitening Testing *For more details, please refer to the catalog or feel free to contact us.

• Human cells
• Animal cells
• Other contract services

At TechnoPro, Inc. and TechnoPro R&D, we provide support for separation and analysis work utilizing various types of chromatography. We have a wide range of experience in separation and analysis tasks, including the examination of membrane separation methods for peptides, the development of quantitative analysis methods for peptides, and stability testing of peptides using these methods. Additionally, we can accommodate requests for screening of extraction methods or screening of separation methods alone, so please feel free to consult with us. [Service Overview] ■ Screening and optimization of extraction methods ■ Screening and optimization of separation methods ■ Protocol development ■ Test analysis/sample preparation *For more details, please refer to our catalog or feel free to contact us.

• Ingredient analysis
• Other Protein Research
• Human cells

We support various research and development activities related to peptides from a multifaceted perspective, including contract synthesis of modified peptides. Our services include "contract synthesis of peptides," which involves various chemical modifications, synthesis of phosphorylated peptides, cyclization, and stapled peptides, as well as "peptide-related contract research support," which encompasses fundamental research on peptide structure-function relationships and structural optimization for pharmaceuticals and functional foods. We are flexible in responding to customer requests, so please feel free to consult with us. 【Services Offered】 ■ Contract synthesis of peptides ■ Peptide-related contract research support *For more details, please refer to our catalog or feel free to contact us.

• Peptide synthesis
• Other protein analysis
• Other contract services

"Expression and purification of recombinant proteins" is a service that accepts the expression and purification of proteins using various expression systems, from vector and host selection to gram-scale purification. We can accommodate requests for only gene acquisition and construction of protein expression vectors, selection of optimal hosts, recovery of host extracts, as well as small-scale and large-scale needs. Additionally, we also accept requests for protein expression and purification after obtaining stable expression cells, so please feel free to consult with us. 【Features】 ■ Capable of accommodating individual requests ■ Accepts expression and purification of proteins using various expression systems *For more details, please refer to the catalog or feel free to contact us.

• Other purification and extraction
• Expression vector
• Other contract services

"Production of Gene-Introduced Cells" is a comprehensive service that handles everything from the construction of gene expression vectors to gene expression analysis for the production of gene-introduced cells. We can also accommodate requests for just obtaining genes and constructing gene expression vectors, only gene introduction, or only viral infection and expression analysis. Additionally, we offer services for gene expression analysis of cells after transient expression and preparation of viral particles, so please feel free to consult with us. [Features] ■ Comprehensive service for the complicated production of gene-introduced cells ■ Capable of accommodating individual requests *For more details, please refer to our catalog or feel free to contact us.

• Analysis and sequencing services
• Expression vector
• Human cells

TechnoPro, Inc. and TechnoPro R&D Co., Ltd. are companies primarily engaged in research and development specialized in the fields of chemistry and biotechnology, as well as clinical development in the pharmaceutical sector. Since its establishment, the company has built a strong track record in Japan, receiving numerous requests for cutting-edge projects such as cell experiments related to regenerative medicine, genetic analysis, and material development for fuel cells and solar cells. As experts in research and development, we have been involved in various client projects, enhancing our research skills and experience, and we are committed to strongly supporting our customers' R&D efforts. If you have needs related to the fields of chemistry and biotechnology, please do not hesitate to contact us. [Business Overview] ■ Research and development specialized in the fields of chemistry and biotechnology, as well as clinical development in the pharmaceutical sector. *For more details, please refer to our catalog or feel free to contact us.

• Research and technical staffing
• Technology Development
• Other bio-related products and services