プロテインシンプルジャパン List of News Articles

The latest published paper utilized Abby. This will be an online seminar featuring Associate Professor Yosuke Katsuta from the Graduate School of Advanced Science and Technology, Kumamoto University, who is also a co-founder of StapleBio. He is working on RNA hacking technology development aimed at altering the higher-order structure of target mRNA using short nucleic acids named Staple nucleic acids, with the goal of controlling gene expression. He will present the latest data focusing on the results of cell experiments and animal experiments in the development of this technology. Related paper on the lecture content: "Staple oligomers induce a stable RNA G-quadruplex structure for protein translation inhibition in therapeutics" | Nature Biomedical Engineering

<Title> Development of Gene Expression Control Technology through RNA Hacking In the latest presentation paper, we have utilized Abby. Associate Professor Yosuke Katsuta from Kumamoto University Graduate School of Advanced Science and Technology, Analytical Chemistry Laboratory (also co-founder of StapleBio), will be giving a presentation in an online seminar. He is working on the development of RNA hacking technology aimed at controlling gene expression by utilizing short nucleic acids named Staple to change the higher-order structure of target mRNA. He will present the latest data focusing on the results of cell experiments and animal experiments in the development of this technology. Related paper on the presentation content: Staple oligomers induce a stable RNA G-quadruplex structure for protein translation inhibition in therapeutics | Nature Biomedical Engineering

Jointly Hosted BioPharma Webinar with Japan Waters Corporation <Program> - Rapid and accurate quality characterization of pharmaceuticals using LC/MS (Liquid Chromatography Mass Spectrometry) and icIEF (capillary isoelectric focusing) - Case studies of real-time monitoring during processes using UPLC (Ultra-High Performance Liquid Chromatography) and MALS (Multi-Angle Light Scattering Detector)

Title: ~Bioprocess Strategy~ LC-Based Approach for Bioprocess Engineers <Program> - Rapid and accurate quality characterization of pharmaceuticals using LC/MS (Liquid Chromatography Mass Spectrometry) and icIEF (capillary isoelectric focusing). - Case studies of real-time monitoring during processes using UPLC (Ultra-High-Performance Liquid Chromatography) and MALS (Multi-Angle Light Scattering Detector).

A high-throughput fully automated staining and imaging device capable of simultaneous detection of RNA and proteins. The single-cell spatial multi-omics COMET is also newly listed.

Single-cell isolation is a necessary step for various applications, ranging from the development of high-yield, stable cell lines for biopharmaceutical manufacturing to the development of CRISPR-edited iPSCs for disease modeling and drug development. Traditionally, single cells have been isolated using manual approaches (such as limiting dilution) or FACS to generate clonal cell lines. However, these approaches can be labor-intensive, yield low results, and extend development timelines. Bio-Techne's Pala cell sorting and single-cell dispenser automate single-cell isolation through dual-laser fluorescence and gentle cell dispensing, improving hit rates and quality while saving time and yielding better results.

You can learn how the fully automated dyeing and imaging device COMET integrates the RNAscope HiPlex Pro assay and continuous immunofluorescence (seqIF) to provide spatially separated insights using off-the-shelf primary antibodies. We will guide you through a fully automated workflow that makes spatial multi-omics accessible in any laboratory. This webinar will provide essential knowledge and tools for those who are new to RNAscope HiPlex Pro as well as for those looking to enhance their current workflows.

Investigation of the TREM2 signaling mechanism in iPSC-derived microglia through high-throughput multiplex capillary western analysis using simple western and validation antibodies, along with the introduction of the new model Leo.