サン・メディカ List of Products and Services

San Medica will celebrate its second anniversary this May as a member of the HOKTO Group. We aim to promote a delicious and healthy "mushroom culture" in Japan and around the world. Within the HOKTO Group, which advocates for "active mushroom consumption," our company focuses primarily on utilizing and spreading the functional benefits of mushrooms. Therefore, we have prepared some wonderful gifts featuring HOKTO mushrooms. We have gathered products that pique your interest, such as HOKTO's special "Luxury Curry made with Whole Eringi Mushrooms," "Luxury Curry made with HOKTO Mushrooms," and "Mushroom Takikomi Gohan Mix," among others. *These will be given away through a lottery to those who download our materials or make inquiries. *This offer is limited to the period from January 4 (Friday) to January 31 (Thursday).

• Exhibition

San Medica, which conducts research and development of health and functional foods and materials, is currently distributing free materials explaining the relationship between dementia and "Amiloban." "Amiloban" is a fat-soluble substance derived from Lion's Mane mushroom, patented in 2007. Its ability to suppress the toxicity of amyloid beta, a cause of Alzheimer's disease, has been confirmed. This material introduces the effects of "Amiloban" on cognitive function improvement based on multiple cases. [Contents (excerpt)] ■ Current status of cognitively impaired elderly (2010) ■ Dementia treatment drugs approved in Japan ■ Abnormal protein amyloid beta and Alzheimer's type dementia ■ Cases of cognitive function improvement ■ Verification targeting young people (long sleep duration), etc. *For more details, please refer to the PDF material or feel free to contact us.

• Food/beverage functional materials
• Pharmaceutical materials and carriers

Sun Medica, which conducts research and development of health and functional foods and materials, is currently distributing free materials explaining the relationship between "high blood sugar, PCOS (polycystic ovary syndrome), and 'glucan.'" "Glucan" is a substance derived from maitake mushrooms that regulates insulin action. It has been reported that glucan, a water-soluble glycoprotein extracted from maitake, has ovulation-inducing effects and improves insulin resistance in cases of OHSS (Ovarian Hyperstimulation Syndrome) and multiple pregnancies induced by ovulation stimulation with HMG and FSH. This material provides a detailed explanation of clinical trials and their results. [Contents (excerpt)] ■ About glucan ■ Ovulation rates with glucan and Clomid administered alone ■ Ovulation rates with glucan + Clomid administered together ■ Effects of glucan in Clomid-resistant PCOS ■ How to utilize glucan, etc. *For more details, please refer to the PDF document or feel free to contact us.

• Pharmaceutical materials and carriers

This document introduces a type of mussel known as "green-lipped mussel" (Moeigiigai) that inhabits the waters of New Zealand (NZ). It has been a food source familiar to the Māori people for a long time, and research institutions in the United States, Germany, and Australia are primarily conducting studies on its effects in alleviating symptoms of arthritis and rheumatism. [Contents (excerpt)] ■ What is the green-lipped mussel (Moeigiigai) ■ An old yet new natural material ■ Do the Māori have arthritis? ■ Quality management ■ Environmental reasons for being one of the safe mussels, etc. *For more details, please refer to the PDF document or feel free to contact us.

• Food ingredients (powder)
• Food ingredients (other)
• Other food and beverage ingredients

The document provides a detailed explanation of insulin resistance. Carbohydrates consumed in the diet are broken down into glucose in the body and absorbed by insulin. When insulin does not function properly, glucose that is not absorbed remains in the bloodstream (leading to high blood sugar levels), prompting the secretion of more insulin (resulting in high insulin levels). With continued exposure to insulin, cells become less responsive to it and are unable to process glucose. This inefficient functioning of insulin is known as insulin resistance. The document also elaborates on various symptoms that arise due to insulin resistance. **Examples of symptoms related to insulin resistance (excerpt):** - High blood sugar, high blood pressure, high lipid levels - Metabolic syndrome - Diabetes - Polycystic ovary syndrome - Sleep apnea, etc. *For more details, please refer to the PDF document or feel free to contact us.*

• others

Grislin is a glycoprotein derived from maitake mushrooms that is effective in the treatment of PCOS (polycystic ovary syndrome). This document introduces testimonials from users who have actually used Grislin for PCOS treatment. For example, a woman in her 20s said, "After about a month of taking it, I no longer had irregular bleeding, and my menstrual irregularity improved," while a woman in her 30s shared, "I started ovulating from the month I took it, and my menstrual cycle became regular at 35 days." We have included numerous testimonials from various cases. [Excerpt of Contents] - "After using it for 3 months, my menstrual cycle has become regular" (woman in her 20s) - "After using it for 2 months, I started ovulating in response to infertility treatment injections and medications" (woman in her 30s) - "After using it for 1 month, my irregular bleeding and menstrual irregularity improved" (woman in her 20s) - "I started ovulating from the month I took it, and my menstrual cycle stabilized" (woman in her 30s), etc. *For more details, please refer to the PDF document or feel free to contact us.

• others

This document includes numerous reports on cases using Yamabushitake extract. In the case of an 80-year-old woman, Yamabushitake extract was used in the sixth year after symptoms began. Within six months of starting the treatment, she showed remarkable changes, such as being able to name objects and perform two-digit subtraction. This document also details other cases, including a 79-year-old woman whose dementia score increased from 17 to 24, and an 81-year-old woman whose score rose from 20 to 27, providing a thorough account of the progress until the effects were observed. [Contents (excerpt)] ■ Six years of an elderly patient diagnosed with depression ■ Case reports 1-4 on Yamabushitake extract ■ [Revised] Hasegawa's Dementia Scale *For more details, please refer to the PDF document or feel free to contact us.

• Other Protein Research

This document explains a study conducted using rats to investigate the effects of Yamabushitake extract on learning and memory abilities. When rats were released into a tank with a hidden platform, they learned to find a resting place while swimming and remembered the location of the platform. In this study, dementia-affected rats were given Yamabushitake extract, and the time taken to reach the platform was measured and compared with normal rats. The results showed that dementia rats given the extract reached the platform significantly faster than those without it. The differences in reaching times compared to normal rats, as well as details and results of subsequent memory tests, are also presented in detail using graphs and figures. [Contents (excerpt)] - Morris water maze test - Learning ability test results - Memory test results - Increase in brain NGF due to Yamabushitake extract, etc. *For more details, please refer to the PDF document or feel free to contact us.

• Other Protein Research

The "[Revised] Hasegawa Dementia Scale" is a simple questionnaire used to investigate the possibility of dementia. In the early stages, it can be difficult to distinguish dementia from normal age-related forgetfulness. Please use it for early detection. 【Questionnaire Items (Excerpt)】 ■ How old are you? ■ What is today’s date, including the year, month, and day? What day of the week is it? ■ Where are we right now? ■ Please repeat the three words I will say next. ■ Subtract 7 from 100 in order, and so on. *For more details, please refer to the PDF document or feel free to contact us.

• others

Comparison data of Grislinn and traditional Chinese medicine (Shakuyaku Kanzoto) for those diagnosed with PCOS (Polycystic Ovary Syndrome), as well as comparison data with Clomiphene, are provided. In addition to the evidence, user testimonials are also included. 【Contents】 ■ What is Grislinn? ■ Insulin resistance improvement effects ■ The relationship between Polycystic Ovary Syndrome (PCOS) and insulin resistance ■ Results of various comparative studies and observations ■ User testimonials *For more details, please download the PDF or feel free to contact us.

• Food/beverage functional materials

Grislin is one of the components derived from maitake mushrooms. We are offering a pamphlet that includes information on the function of insulin, the relationship with metabolic syndrome, and knowledge about lifestyle-related diseases, providing a detailed explanation of the effects of grislin. It is packed with useful health information! 【Contents】 ■ What is grislin? ■ Function of insulin ■ Causes of metabolic syndrome ■ Reasons for increased blood sugar levels, etc. *For more details, please download the PDF or feel free to contact us.

• Food/beverage functional materials

It is said that the Maori people of New Zealand have very few cases of arthritis or rheumatism, and there is a song that has been passed down stating, "If you eat green-lipped mussels, the pain will disappear." Research on the application of green-lipped mussels for arthritis began in the 1970s, and now there are many research presentations and papers available. Here is a simple explanation of green-lipped mussels. [Content] ■ Explanation of the mechanism of joint pain ■ Introduction of the components and effects of green-lipped mussels ■ Checklist for joint health *For more details, please download the PDF or feel free to contact us.

• Food/beverage functional materials

Expect great things for brain health! This handbook clearly explains the components of Yamabushitake extract, Amyloban and Hericenones. The average life expectancy of Japanese people has significantly increased, leading to the era of living to 100 years. Along with this, the number of elderly individuals with dementia is also rising year by year. How can we live long with a "healthy brain"? The hints are here. 【Contents】 ■ Be cautious if you notice an increase in "this, that, and the other"! ■ The difference between forgetfulness and dementia; early detection is key ■ Cognitive check using the revised Hasegawa Dementia Scale *For more details, please download the PDF or feel free to contact us.

• Food/beverage functional materials

Amiloban is an active ingredient found in Lion's Mane mushroom, which is a material for improving brain function. The useful components of Lion's Mane mushroom, known as "hericenones," have already been recognized as substances extracted from the fruiting body, but a newly discovered substance is "Amiloban," which is a patented component successfully isolated by Mushroom Wisdom, Inc. in the United States (Japan No. 39443399). It is being researched and utilized in various research facilities and clinics both domestically and internationally, including Shizuoka University and China Pharmaceutical University. The raw material, Lion's Mane mushroom, is also enjoyed as an edible mushroom, and its safety is well known. Only Lion's Mane mushrooms cultivated in open fields by contracted farmers are used as raw materials for extraction. Additionally, quality inspections by third-party organizations are conducted on all raw materials. 【Features】 ■ Patented ingredient ■ Promotes the synthesis of nerve growth factor (NGF) ■ Suppresses amyloid beta toxicity ■ Inhibits neuronal cell death *For more details, please download the catalog or feel free to contact us. *If you would like a sample, please let us know through the inquiry form.

• Food/beverage functional materials

Grislin is a glycoprotein (sugar protein) with a molecular weight of approximately 20,000, obtained by fractionally purifying the hot water extract of maitake fruiting bodies. The raw material, maitake, has a long history of consumption and its safety is well known. It is a patented material successfully isolated by Mushroom Wisdom, Inc. (formerly Maitake Products, Inc.) in the United States (Japan No. 4233029, U.S. No. 7214778). For over 10 years, various basic research and clinical trials have been conducted at New York Medical College, Georgetown University, and universities and clinics in Japan. In recent years, it is expected to be applicable in gynecology as a material for addressing metabolic syndrome. 【Features】 ■ Patented ingredient ■ Improvement of insulin resistance ■ Enhancement of insulin sensitivity * For more details, please download the catalog or feel free to contact us. * If you would like a sample, please let us know through the inquiry form.

• Food/beverage functional materials

This is a freeze-dried and powdered product made from the entire New Zealand green-lipped mussel. The "green-lipped mussel" is a green bivalve belonging to the family Mytilidae, found only in New Zealand. It is a type of mussel, similar to the commonly consumed blue mussel (purple-lipped mussel), and its benefits have been scientifically proven in recent years, leading to its widespread use around the world. 【Features】 ■ Strengthens cartilage and connective tissue ■ Reduces pain and inflammation *For more details, please download the catalog or feel free to contact us. *If you would like a sample, please let us know via the inquiry form.

• Food/beverage functional materials

"D-Fraction" is a proteoglycan extracted from maitake mushrooms with an average molecular weight of 1 million, which is a complex active β-glucan that consists of β1-3 glucans with β1-6 branching and β1-6 glucans with β1-3 branching, combined with proteins. As a function, it is expected to activate immune cells, among other benefits. Additionally, quality control is conducted to ensure safety through regular microbiological testing, heavy metal testing, and pesticide residue testing, as well as strict monitoring. [Features] ■ Abundant evidence ■ Safety *For more details, please download the PDF or feel free to contact us. *If you would like a sample, please let us know through the inquiry form.

• Food/beverage functional materials
• Food ingredients (powder)
• Beverage ingredients (powder)