Chemical

日本理化学工業

EstablishmentJuly 20, 1919
capital2000Ten thousand
number of employees48
addressOsaka/Higashiosaka-shi/2-8-18 Nagatō
phone06-6781-0346
last updated：
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日本理化学工業 List of Products and Services

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Analysis equipment

We will respond to various analytical tasks in compliance with GMP, including quality control of pharmaceutical intermediates and the implementation of various validations.

Gas Chromatograph Shimadzu Corporation GC-2014ATF/SPL 4 units Gas Chromatograph Shimadzu Corporation GC-2030AF/HS-20NX 2 units Liquid Chromatograph Shimadzu Corporation Prominence SPD-20A system 6 units Liquid Chromatograph Shimadzu Corporation Prominence SPD-M20A system 2 units Liquid Chromatograph Shimadzu Corporation Prominence SPD-M40 system 2 units Liquid Chromatograph Waters ACQUITY Arc system Infrared Spectrophotometer Shimadzu Corporation IR Affinity-IS 2 units Ultraviolet-Visible Spectrophotometer Shimadzu Corporation UV-2600i 2 units Karl Fischer Moisture Meter (Coulometric Titration) Kyoto Electronics MKC-610 3 units Karl Fischer Moisture Meter (Volumetric Method) Kyoto Electronics MKA-610, MKA-520 Melting Point Measurement Device Japan Buechi M-565 2 units pH Meter Horiba Advanced Techno F-74 12 units Muffle Furnace Yamato Scientific FP313, FUL222FA 2 units Constant Temperature Dryer Advantech Toyo DRN420DB, DRN422DA

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Research equipment

We have equipment that can handle research within the department, ranging from a few milligrams to about 1 kilogram. We will respond according to the situation, including initial assessments and toxicity testing samples.

NMR Bruker AVANCE NEO 400 NMR system QTof-MS Waters Xevo G2-XS Q-tof UPLC Waters ACQUITY UPLC H-Class Bio System HPLC Shimadzu Corporation High-Speed Liquid Chromatograph Prominence 3 units Preparative HPLC Japan Analytical Industry Recycle Preparative HPLC LABO Ace LC-5060 Flash purification system Biotage Isolera one (PDA, ELSD) 3 units Biotage Isolera Dalton2000 Biotage Isolera LS 2 units Dryers Advantech Forced Air Constant Temperature Dryer 3 units Advantech Vacuum Constant Temperature Dryer EYELA Freeze Dryer Ishii Rika Vacuum Sample Dryer TAITEC Centrifugal Concentration Dryer Freezers/Refrigerators Daido Industrial and others Explosion-proof Freezer/Refrigerator 3 units Concentration equipment Büchi Rotary Evaporator x4 Shibata Scientific Medium-sized Rotary Evaporator x2 Continued next.

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Manufacturing equipment

We carry out everything from pilot production to commercial manufacturing (using reactors and reduction tanks ranging from 50L to 4,000L).

Reactor 3,000L~4,000L 4 units GL Reactor 2,000L~2,500L 4 units GL Reactor 1,000L 1 unit SUS Reactor 50L~1,000L 10 units GL Reduction tank 50L~1,000L 2 units Hastelloy/SUS Centrifuge 36~48 inch 6 units SUS Centrifuge 24~26 inch 2 units SUS Centrifuge 48 inch 1 unit Hastelloy Centrifuge 16 inch 1 unit Hastelloy Dryer conical 1.5m3 1 unit SUS Dryer conical 0.5m3 1 unit SUS Dryer shelf type 6 units SUS Pressurized filter 4 units SUS, 1 unit PE

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New Technology: Flow Chemistry

Would you like to try a reaction that cannot be done in a reaction vessel?

Research Scale YMC-made microreactor (two-liquid mixing, hydrogenation reaction, photoreaction) Saida FDS-made microwave flow reaction device Pilot Scale Nakamura Super Hard-made flow-type two-liquid reaction system (Hastelloy) Manufacturing Scale Kobe Steel-made stacked multi-channel reactor (SMCR)

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[Research ~ Process] Conducted from initial examination to process development.

The research department will conduct initial examinations and process evaluations. We will propose the optimal method using various equipment.

Initial consideration (batch or flow consideration) ↓ ↓ Process consideration implementation ↓ ↓ Pilot consideration

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Research and development, as well as manufacturing, of pharmaceutical intermediates and research reagents.

We specialize in the production of heterocyclic compounds, including kinorinone (carboschiral) derivatives, indole, and azepinone-related compounds.

Carbostyril, 2(1H)-Quinolinone derivatives 3,4-Dihydro-1H-quinolin-2-one derivatives Indole derivatives 1, 3, 4, 5-Tetrahydro-benzo[b]azepin-2-one derivatives Aryl piperazine Heterocyclic compound

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