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We would like to introduce the clinical trials conducted by our company. The project concerning achondroplasia received support from the Japan Agency for Medical Research and Development (AMED) and began a Phase 1 trial in July 2020 at a domestic clinical trial facility to investigate the safety, tolerability, and pharmacokinetics of RBM-007, which was conducted until May 2021. Regarding the Phase 2 trial of this project, it has been adopted as a pre-commercialization support project for orphan drugs by AMED for three years starting from the fiscal year 2021. [Main Trials] ■ Phase 1 Clinical Trial ■ Early Phase 2 Observational Trial ■ Early Phase 2 Clinical Trial ■ Early Phase 2 Long-term Clinical Trial *For more details, please refer to the PDF materials or feel free to contact us.

• Other Testing Contract

We would like to introduce the clinical trials conducted by our company. As a clinical trial targeting exudative age-related macular degeneration (wet AMD), a Phase 2 clinical trial was conducted in the United States after the implementation of a Phase 1/2a clinical trial, aimed at confirming the clinical proof of concept (POC) of multiple administrations of RBM-007. Furthermore, a physician-led clinical trial was conducted in the United States to evaluate the efficacy and safety of RBM-007 monotherapy in treatment-naive wet AMD patients. 【Main Trials】 ■ Randomized double-blind trial ■ Open-label trial ■ Physician-led clinical trial *For more details, please refer to the PDF materials or feel free to contact us.

• Other Testing Contract

We would like to introduce our "Aptamer Drug Discovery Technology." Our core drug discovery technology, the "RiboART System," is built on comprehensive technologies, knowledge, and experience related to aptamer drug discovery, creating a platform (drug discovery foundation) that can be widely applied to the generation of new drug candidates. By using this system, it is possible to create various new drugs that are not limited to specific diseases or target proteins. 【Flow】 ■ SELEX method ■ Binding property measurement ■ Shortening, re-SELEX, chemical modification ■ Cell testing ■ Animal testing ■ Toxicity testing *For more details, please refer to the PDF document or feel free to contact us.

• Other Protein Research

We would like to introduce the features of the "aptamer" that we handle. Single-stranded nucleic acids form various three-dimensional structures according to their sequences. Utilizing this structural capability, these nucleic acid molecules can bind to target proteins and inhibit or regulate their functions. Please feel free to contact us when you need assistance. 【Features】 ■ Creates a three-dimensional structure that fits the shape of the protein for binding, known as "shape capture." *For more details, please refer to the PDF materials or feel free to contact us.

• Pharmaceutical Intermediates

Our core drug discovery technology, the "RiboART (Ribomic Aptamer Refined Therapeutics) System," is built on comprehensive technologies, knowledge, and experience related to aptamer drug discovery, establishing a platform (drug discovery foundation) that can be universally applied to the creation of new drug candidates. By using the "RiboART System," it is possible to develop various new drugs that are not limited to specific diseases or target proteins. Please feel free to contact us if you have any inquiries. 【Features of Aptamer Pharmaceuticals】 ■ Strong target binding ability ■ Few restrictions on targets ■ Easy chemical modifications ■ Production through chemical synthesis ■ Low antigenicity *For more details, please download the PDF or contact us.

• Other contract manufacturing
• Technology Development