高研 List of Products and Services

FibColl(R) high permeability atelocollagen inserts for 24-well plates are a new type of cell culture insert that utilizes membranes made solely from atelocollagen. Unlike other products that use plastic membranes coated with collagen, these inserts do not clog pores and possess the fibrous structure of atelocollagen, allowing for cell culture in an environment that mimics in vivo conditions. The fine pore structure between atelocollagen fibers allows for the passage of molecules exceeding 600 kDa, making them suitable for barrier function evaluation and co-culture. 【Features】 ■ The atelocollagen membrane has permeability for molecules exceeding 600 kDa. ■ It is possible to create a barrier function evaluation model through the formation of tight junctions in epithelial cells. ■ This hanging-type cell culture insert is designed for ease of use, taking into account the operability of medium exchange and membrane recovery after culture. ■ The membrane is biodegradable, allowing for use in cell sheet transplantation. *For more details, please download the PDF or contact us.

• Other Culture

We offer the honeycomb-structured sponge made of atelocollagen, called '3D Honeycomb Boosted.' 3D Honeycomb Boosted is a high-density three-dimensional culture (3D culture) carrier processed from atelocollagen into a sponge-like scaffold with honeycomb-shaped through-holes. It is sized at Φ5mm × height 5mm, allowing for cell culture on a scale of 106 cells, comparable to a 35mm dish. 【Features】 ■ The honeycomb structure facilitates easy nutrient supply and waste release, allowing cells to proliferate throughout the entire inner surface of the pores. ■ It has high resilience, returning to its original shape even after compression. ■ Cells can be easily recovered through trypsin treatment. ■ It is biodegradable, making it suitable for transplantation. ■ It is immersed in PBS, eliminating the need for static electricity measures and defoaming. *For more details, please download the PDF or contact us.

• Other Culture
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• Other research reagents

"Aterocollagen Coat β-TCP" is a carrier coated with biocompatible atelocollagen, widely used as a bone filler material due to its excellent bone conductivity, which contains β-tricalcium phosphate (β-TCP). It can be used for bone induction experiments using bone-forming factors in vitro/in vivo and for bone remodeling studies. 【Specifications】 ■ Size: φ3×1mm ■ Type: Honeycomb / Flat ■ Number of through holes: 37 / None ■ Pore cross-sectional area: 0.07mm² / None ■ Pore size: Approximately 300μm / - ■ Sterility guarantee: Yes ■ Storage: Room temperature *For more details, please refer to the PDF document or feel free to contact us.

• Other Culture
• Culture medium
• Other research reagents

We offer a high-density culture (mass culture) microcarrier called "Collagen Microspheres," which is formed into bead-like shapes using atelocollagen. It is used for suspension culture and static culture of fibroblasts, epithelial cells, osteoblasts, etc., and is effective as a scaffold material to maintain cell function. 【Features】 ■ Made solely from collagen fibrils, allowing for the creation of a culture environment similar to that in vivo. ■ Cells can be easily recovered through collagenase treatment. *For more details, please download the PDF or contact us.

• Other Culture
• Culture vessel
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We handle a "permeable collagen membrane" made of atelocollagen, which has high transparency and material permeability. By seeding cells on both sides of the membrane, it is possible to observe interactions between cells without them mixing. Additionally, when epithelial cells are cultured on this membrane, it allows for the absorption of nutrients and the excretion of metabolic products through the collagen membrane, enabling the cultivation of cells with polarity, similar to in vivo conditions. [Applications] ■ Membrane-based culture ■ Co-culture ■ Cell sheet transplantation *For more details, please download the PDF or contact us.

• Other Culture
• Culture vessel
• Other research reagents

We offer the random pore sponge made of atelocollagen, "Collagen Sponge Mighty." By seeding cells and culturing them under mechanical stimulation (repeated loading), it is possible to evaluate cell function in conditions close to those of a living organism, such as in arthritis models. It can also be used as a scaffold material for three-dimensional (3D) culture. 【Features】 ■ A strong collagen sponge that does not collapse under compression loads of up to 40 kPa ■ Sized for use in 96-well plates ■ Biodegradable, making it suitable for transplantation *For more details, please download the PDF or contact us.

• Other Culture
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AteloGene(R) is an in vivo siRNA/miRNA introduction kit that forms a complex suitable for introduction into the body by mixing atelocollagen as the main component with nucleic acids at appropriate concentrations and ratios. By complexing, it suppresses the degradation of nucleic acids by nucleic acid-degrading enzymes, allowing for efficient introduction into the cells of tissues in vivo. 【Features】 ■ Forms a complex with nucleic acids, protecting them from degradation ■ Suppresses immune responses to double-stranded RNA ■ Minimal gene expression fluctuations due to toxicity, with clear nucleic acid introduction effects ■ Options for "Local Use," which releases nucleic acids from the gel, and "Systemic Use," which delivers without forming a gel ■ AteloGene(R) Local Use "Quick Gelation" improves gelation speed, introduction efficiency, and convenience compared to conventional products *For more details, please download the PDF or contact us.

• Other Nucleic Acid/DNA Research

We offer "3D Ready Atelocollagen," which eliminates the need for neutralization and mixing with culture media required for gelation of atelocollagen, allowing for easy and stable three-dimensional culture (3D culture). Our high-purity atelocollagen derived from bovine skin is pre-mixed with DMEM, so it can be used immediately by simply mixing it with cells and warming it up. Additionally, there is no need to worry about fiber formation during preparation or cell sedimentation during gel formation, making it especially recommended for those starting three-dimensional culture (3D culture). 【Features】 ■ Ready-to-use atelocollagen for three-dimensional culture (3D culture) ■ Mixed with DMEM Low Glucose or High Glucose ■ Simple operation of mixing with cells and warming to form collagen gel ■ Suppresses cell sedimentation during gel formation, achieving stable three-dimensional culture (3D culture) *For more details, please download the PDF or contact us.

• Other Culture
• Culture medium
• Other research reagents