福島セルファクトリー List of Products and Services

We offer contract services for "freeze-drying." Since the processing is done at low temperatures, it is less likely for components to decompose or deteriorate, allowing for high-quality preservation. Additionally, it can suppress oxidation, spoilage, and microbial growth in samples, enabling long-term storage. Drying at low temperatures also helps to reduce aggregation. 【Advantages】 ■ Quality preservation ■ Long-term storage ■ Suppression of aggregation and inactivation *For more details, please refer to the PDF document or feel free to contact us.

• Other contract services
• Other protein analysis
• Freeze Dryer

With a small amount of sample, detection and quantification of target molecules related to up to 500 types of inflammation, diseases, cancer, cell signaling, cell proliferation, apoptosis, toxicity, and more can be performed. Existing kits are panelized with a rich lineup of these targets, and there is a wide variety of biological species, including humans, mice, rats, as well as primates, dogs, cats, pigs, and cows. You can choose a kit that suits your needs from these options, or we can also create a custom kit tailored to your requirements. Measurements can be made with as little as 12.5 µL per assay (for human serum/plasma samples). Multiple protein concentration measurements can be performed from a single sample. We will propose the optimal evaluation system based on the target molecules.

• Other cell research

We would like to introduce our "Molecular Interaction Analysis Service." Utilizing the high level of expertise and extensive experience gained from fundamental research, we can accommodate a variety of requests, from screening to kinetics analysis. Additionally, we offer suggestions for sensor chip selection and measurement tailored to our customers' objectives. We provide high-precision analysis data at a satisfactory price and delivery time. 【Examples of Molecular Interactions】 ■ Antigen ⇔ Antibody ■ Protein ⇔ Protein ■ Protein ⇔ Peptide ■ Protein ⇔ Low Molecular Weight Compound ■ Protein ⇔ Biotinylated Sample ■ Protein ⇔ His-tagged Sample *For more details, please refer to the PDF document or feel free to contact us.

• Analysis and sequencing services

We would like to introduce our "Contract Services using Flow Cytometry." In "Cell Characterization Analysis," we flow a suspension of cells through a narrow tube to align them in a single file, using fluorescent dyes to count each particle in sequence, allowing for rapid and highly sensitive analysis of cell characteristics. In "Cell Sorting," we sort only the target cells through multi-parameter analysis. We also accommodate expanded culture after sorting. [Cell Characterization Analysis - Analysis Contents] ■ Cell Surface Marker Analysis ■ Cytokine Measurement ■ Cell Activation Analysis ■ Cell Cycle Analysis ■ Apoptosis Analysis, etc. *For more details, please refer to the PDF document or feel free to contact us.

• DNA/RNA sample delivery
• Cell culture contract service
• Analysis and sequencing services

We would like to introduce our "Cell and Sample Storage / Cell Culture and Stock Preparation Services." In our "Cell and Sample Storage Service," you can choose a management grade that suits the nature of your samples. The inbound and outbound operations, as well as management tasks, are handled exclusively by staff who have received GMP training, allowing us to provide a high-quality storage environment. Additionally, in our "Cell Culture and Stock Preparation Service," researchers with extensive experience in culturing a wide variety of cells carry out the work. 【Features of the Cell and Sample Storage Service】 ■ Reliable security ■ Continuous monitoring of facilities ■ Contingency planning for emergencies ■ Ability to select a management grade that suits the nature of the samples - GMP grade 1: Storage of cell banks directly used for the manufacture of pharmaceuticals - GMP grade 2: Storage of experimental cells, etc., from cell banks not directly used for the manufacture of pharmaceuticals *For more details, please refer to the PDF document or feel free to contact us.

• DNA/RNA sample delivery
• Cell culture contract service

Our company provides problem-solving research support services. Utilizing the technologies and know-how cultivated through the Fukushima Pharmaceutical Industry Support Base Project, we offer research support services for pharmaceutical development. If you have any requests or concerns regarding cell storage, specimen storage, cell culture and stock preparation, cell characterization analysis, cell sorting, molecular interaction analysis, immune-related evaluation tests, etc., please feel free to consult with us. 【Business Content】 ■ Cell and specimen storage ■ Management and operation of GMP facilities ■ Human antibody production ■ Biacore measurement ■ Contract analysis such as FCM analysis *For more details, please refer to the PDF document or feel free to contact us.

• DNA/RNA sample delivery
• Genome analysis contract
• Analysis and sequencing services

Our company offers contract services for "immune-related evaluation tests." When immune cells are activated, they produce various cytokines. Major cytokines include tumor necrosis factor, interferon, and interleukins. By measuring the induced amounts of these cytokines using ELISA or FCM, we can investigate immune activity. For example, by treating immune cells with test substances and measuring the changes in various induced cytokines, it is possible to evaluate the immunomodulatory ability of the test substances. Additionally, evaluating natural killer activity and antibody-dependent cellular cytotoxicity is essential for assessing antitumor effects. 【Features】 ■ Measurement of cytokines produced by immune cells treated with test substances ■ Evaluation of ADCC activity and NK activity *For more details, please refer to the related links or feel free to contact us.

• Other contract services
• Other Testing Contract
• Other analysis and evaluation services

We offer a contract service for "molecular interaction analysis." This system (SPR analysis) allows for real-time monitoring of molecular interactions by detecting mass changes without using any labels. From the obtained data, binding rate constants, dissociation rate constants, and dissociation constants can be calculated. 【Features】 ■ An extremely effective tool for understanding one-on-one biophysical interactions ■ Capable of accommodating various requests from screening to kinetics analysis ■ Provides high-precision analytical data at a reasonable price and delivery time *For more details, please refer to the related links or feel free to contact us.

• Other contract services
• Other protein analysis
• Other Numerical Analysis Contract

We offer contract services for "cell sorting." There are several types of equipment, including those that control droplets using air pressure, those that eject droplets using piezo dispensers, and those that suction cell suspensions with chips. The detection systems for the sorted cells also vary, utilizing lasers or cameras. We perform sorting using a cell sorter and CellenONE. The cells sorted as single cells can be used for various applications such as PCR analysis and cloning. **Features of Single Cell Sorting** - We can propose sorting methods tailored to customer requests. - Sorting based on multiple parameters. - Cell sorters capable of high-speed sorting of up to four types of cell populations are useful. - Sorting from rare cell populations with low numbers. - CellenONE is suitable as it minimizes loss during sorting. *For more details, please refer to the related links or feel free to contact us.*

• Other contract services
• Other cell research

We offer a contract service for "cell property analysis." This method involves flowing a suspension of cells through a narrow tube to align them in a single file, and using fluorescent dyes to count individual particles in sequence, allowing for rapid and highly sensitive analysis of cell properties. The key difference from microscopy is that the data obtained from the optical detection system is processed not as images of the cells, but as a set of measurement values. 【Features】 ■ Objective measurement of tens of thousands of cells per second ■ Highly sensitive quantitative measurements ■ Simultaneous measurement of multiple parameters ■ Ability to isolate specific cell populations *For more details, please refer to the related links or feel free to contact us.

• Other contract services
• Other Analysis

We offer contract services for "cell culture and stock preparation." We produce lymphoblastoid cell lines (LCL) from PBMC and create stocks of culture supernatant and cells. Additionally, we perform the culture of adherent cells, suspended cells, hybridomas, and protein-producing cells, and we can store them at our cell storage facility. 【Features】 ■ Researchers with extensive experience in culturing a variety of cells handle everything from cell culture to stock preparation. ■ The personnel in charge have completed training in cell culture foundational techniques, ensuring quality. ■ It is also possible to create stocks from cultured cells and store them directly at our storage facility. *For more details, please refer to the related links or feel free to contact us.

• Other contract services
• Cell culture contract service
• Other cell research

Our company offers contract services for "cell storage and specimen storage." In recent years, there has been an increase in the development and manufacturing of biopharmaceuticals, research and development in regenerative medicine and immunotherapy, and an increase in the testing of biological samples, leading to a growing demand for the storage of cell banks and biological samples. To prepare for unforeseen circumstances such as earthquakes and disasters, we recommend that important cells and samples be stored in a reliable facility in a distributed manner. 【Features】 ■ Obtained pharmaceutical manufacturing license (biological product category) ■ Storage grades tailored to customer needs - GMP Grade 1: Storage of cell banks directly used in the manufacturing of pharmaceuticals - GMP Grade 2: Storage of development-stage cell banks not directly used in pharmaceutical manufacturing, cell banks related to regenerative medicine, and cells for research purposes *For more details, please refer to the related links or feel free to contact us.

• Other contract services