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Timegate Raman spectroscopy achieves extremely high temporal resolution and sensitivity compared to traditional continuous wave Raman spectroscopy by combining pulsed lasers with CMOS-SPAD (Single Photon Avalanche Diode) sensors. Utilizing the "avalanche phenomenon," which amplifies electrons from a single photon, this technology can detect even weak light, allowing for accurate capture of faint Raman scattering signals. It excels particularly in measurements under low light conditions and in high-speed reaction monitoring. The application of Timegate Raman technology enables highly accurate continuous monitoring of bioreactors. First, it provides realistic Raman spectra with fluorescence removed, expanding its applicability to cell cultures where traditional Raman techniques could not be used due to the influence of fluorescence signals. Second, this technology achieves the separation of signals from cells and culture media at the hardware level. Third, Timegate Raman technology also allows for monitoring changes in cell density. By detecting signals per pulse and separating the origins of the signals, information regarding changes in cell density can also be obtained.

The elimination of the effects of fluorescence, which has been difficult with conventional Raman spectroscopy, is achieved through Timegate's unique picosecond time-resolved technology. Analysis of biological samples and materials with strong fluorescent backgrounds will be possible with unprecedented clarity. Timegate's Timegated Raman technology solves the challenges of traditional Raman spectroscopy. Rental of Timegate Raman spectrometers has begun! We support non-destructive and high-speed analysis of biological materials, battery materials, polymers, and pharmaceuticals. We are accepting rentals of Timegate Raman spectrometers and are also looking for agents.

We will exhibit at the 40th Annual Meeting of the Japanese Pharmaceutical Society. ■ Timegate Corporation Raman Spectroscopy Device (Live Demonstration) A real-time Timegate Raman spectroscopy system that suppresses the effects of fluorescence. It instantly detects changes in crystal growth, polymorphism, and drying processes during the crystallization process, contributing to the optimization of formulation quality. Additionally, it minimizes variability in the manufacturing process of biopharmaceuticals, achieving stable quality control and process optimization. 【Other Products】 ■ Cellexus Corporation Airlift Bioreactor (Panel and Catalog Display) Real-time monitoring of biopharmaceutical production processes is possible through collaboration with Timegate Raman. ■ RheaVita Corporation Spin Freeze-Drying System (Panel and Catalog Display) A groundbreaking spin freeze-drying technology that enables rapid freeze-drying of biopharmaceuticals. ■ Magritek Corporation Desktop NMR System (Panel and Catalog Display) 【Venue Information】 TFT Building, West Wing, 2nd Floor, 3-4-10 Ariake, Koto-ku, Tokyo May 22 (Thursday) to 24 (Saturday), 2025 *Exhibition will be on the 23rd and 24th.