HIGUCHI INC. List of News Articles

We exhibited a booth at the "38th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments," held at Pacifico Yokohama from November 1 (Saturday) to November 3 (Monday). Thank you very much to everyone who visited our booth during the event. Please feel free to consult us regarding the exhibited products. We look forward to your continued support. Exhibited products: • Pyrogen test kit for pyrogenic substances • Drug screening & toxicity testing organ-on-a-chip • High-performance culture system (microenvironment culture)

The 42nd Symposium on Formulation and Particle Design was held at Toki Messe (Niigata Convention Center) from October 30 (Thursday) to 31 (Friday), where we exhibited a booth. We sincerely thank everyone who visited our booth during the event. Please feel free to consult us regarding our products. We look forward to your continued support. Exhibited product: BENEO-Palatinit's galenIQ

Thank you very much for visiting our booth at "BioJapan 2025" held recently. Thanks to your support, we were able to conclude the event successfully. If you have any questions regarding the products you viewed, please feel free to reach out to us. We will respond to inquiries received during the event in due course. We look forward to your continued support of Higuchi Shokai. Exhibited Products 【Testing Process - Alternatives to Animal Testing】 　Drug Screening & Toxicity Testing Organ-on-a-Chip 　Pyrogen Testing Kit for Testing Pyrogenic Substances 【Cultivation Process - Consumables】 　Cell Culture Bags 　Media Bags 　Sampling & Storage Bottles 　Cryopreservation Bags & Vials 　Filtration Depth Filters for Cultivation 【Next-Generation Technology - Cultivation Equipment】 　High-Performance Cultivation Equipment (Microenvironment Cultivation) 　Automated Cultivation Systems

Thank you very much for visiting our exhibition booth at the 50th Formulation and Creation Seminar "Formulation Technology Q&A Corner" held from September 17 (Wednesday) to 18 (Thursday). If you have any questions regarding the products you viewed, please feel free to reach out to us. We will respond to inquiries received during the event in due course. We look forward to your continued support. ▼Exhibited Products: I Holland manufactured pestles, etc. - Multi-chip pestle - XDF pestle - Rotary head pestle - Alignment tool - TMS (management software) - TSAR (predicts optimal coating)

Thank you very much for visiting our booth at "INCHEM TOKYO 2025," held at Tokyo Big Sight from September 17 (Wednesday) to 19 (Friday). Thanks to your support, we were able to conclude the event successfully with a great deal of interest. We would also like to express our sincere gratitude to everyone who participated in the seminars during the event. If you have any questions or additional requests regarding the products and technologies we introduced, please feel free to contact us. We will respond to the inquiries received during the event in due course. We appreciate your continued support of Higuchi Shokai and look forward to serving you in the future.

We are pleased to announce that we will be exhibiting at INCHEM TOKYO 2025. During the event, we will hold the following seminar at the venue. We sincerely look forward to your visit. ◆ Main Exhibits Biar's liquid sampling valve We will demonstrate its installation on a liquid transfer line, so please experience the actual sampling procedure. ◆ Seminar Information 【Safe and Easy Sampling of All Risk Liquids】 Introduction to Inline Liquid Sampling Systems Risk liquids, such as those subject to risk assessment, require minimizing operator exposure during sampling. We will introduce a safe and easy liquid sampling system that does not compromise productivity or workability, using real examples. (1) September 17 (Wed) 15:30 - 16:40, Venue 2 (2) September 19 (Fri) 10:30 - 11:20, Venue 2 *Capacity: 70 people each (Pre-registration required, free admission)

We exhibited at the "9th Bio Pharmaceutical EXPO" held at Tokyo Big Sight from July 9 to 11, 2025! Thank you very much to everyone who visited us. Main Exhibited Products 【Solid Dosage Form Related Products】 Mixer, Torque, Rheometer Tabletop Tablet and Granule Coating Equipment Powder Sampler IVIVC Dissolution Tester BIO-DIS III Functional additives for improving the solubility of poorly soluble drugs Pharmaceutical cleaning agents compatible with cleaning validation Granulated lactose developed for direct compression, spray-dried lactose Tablet press mortar and pestle, reducing compression time by up to 50% Functional ready-to-fill capsules galenIQ Isomalt Hydrate, and others 【Bio Pharmaceutical Related Products】 Single-use Depth Filter Single-use Mixer Bag System Single-use Assembly Bag Culture Bag SafeCell Pyrogen Test Kit (MAT Test Method) instaCELL High-precision Incubator AVATAR ODYSSEY Biomimetic System Organ-on-a-Chip, and others

Thank you very much for visiting our booth at the 52nd Annual Meeting of the Japanese Society of Toxicology held at the Okinawa Convention Center from July 2 to 4, 2025. Thanks to your support, we were able to conclude the event successfully. If you have any questions regarding the products you viewed, please feel free to reach out to us. We will respond to inquiries received during the event in due course. We look forward to your continued support of Higuchi Shokai. Exhibited Products: - Heat-generating substance testing kit (MAT testing method) instaCELL - Biomimetic system - Organ-on-a-chip - Culture device (from xcellbio)

Thank you very much for visiting our booth at the "24th Annual Meeting of the Japanese Society for Regenerative Medicine" held at Pacifico Yokohama from March 20 to 22, 2025, during the latest technology introduction corner. Thanks to your support, we were able to conclude the event successfully. If you have any questions regarding the products you viewed, please feel free to reach out to us. We will respond to inquiries received during the event in due course. We appreciate your continued support of Higuchi Shokai. Exhibited Products: - Non-freezing cell preservation solution (Cellgentec) - Single-use bags, sterilized capsule filters (Advanced Microdevices) - Assembly tubes, bottles (WHK BioSystems) - Bags for cell freezing preservation and culture (TECHNO FLEX) - Culture devices (xcellbio)

Thank you very much for visiting our booth at the 41st Annual Meeting of the Japanese DDS Society held at Makuhari Messe International Conference Hall from June 17 to 18, 2025. Thanks to your support, we were able to conclude the event successfully. If you have any questions regarding the products you viewed, please feel free to reach out to us. We will respond to inquiries received during the event in due course. We look forward to your continued support of Higuchi Shokai. Exhibited Products: - Heat-generating substance testing kit (MAT testing method) instaCELL - Biomimetic system Organ-on-Chip - Single-use assembly bag - Depth filter for harvesting

Our company will be exhibiting at CITE JAPAN 2025, which will be held at Pacifico Yokohama for three days starting from May 14 (Wednesday). We understand that you will be busy during this period, but we sincerely look forward to your visit. SENSOL100 has been nominated for the exhibition award. *Voting is possible from the visitor registration page. Product Introduction SENSOL100 is an upcycled silicone alternative made from paste oil, which is discarded during the refining of avocado oil, using patented technology. The estimated annual global production of avocado oil is approximately 160,000 tons. Green Tech has successfully upcycled the paste oil obtained as a byproduct during the refining process using patented technology for sustainable development. It contains high concentrations of palmitic acid and palmitoleic acid, standardizes all fatty acid compositions, and achieves a silky texture with a low melting point (mp 25°C to 40°C) without quality inconsistencies. It is being increasingly utilized as a silicone alternative. This product has received the "BSB Innovation Award® 2024, 3rd place in the NATURAL PRODUCTS category" and the "in-cosmetics® Korea Silver Award," gaining global attention!

Thank you very much for visiting our booth at the "24th Annual Meeting of the Japanese Society for Regenerative Medicine" held at Pacifico Yokohama from March 20 to 22, 2025, during the latest technology introduction corner. Thanks to your support, we were able to conclude the event successfully. If you have any questions regarding the products you viewed, please feel free to reach out to us. We will respond to inquiries received during the event in due course. We look forward to your continued support of Higuchi Shokai. ● Exhibits • Non-freezing cell preservation solution (Cellgentec) • Single-use bags, sterilized capsule filters (Advanced Microdevices) • Assembly tubes, bottles (WHK BioSystems) • Bags for cell freezing preservation and culture (TECHNO FLEX) • Culture devices (xcellbio)

On January 10, 2025, we held an exhibition at the "2nd Academic Symposium of the MPS Practical Promotion Council" at Tower Hall Funabori (Edogawa Ward, Tokyo). Thank you very much to everyone who visited our booth. Thanks to your support, we were able to conclude the event successfully. If you have any questions regarding the products we introduced at the venue, please feel free to reach out to us. We will respond to inquiries received during the event in due course. We appreciate your continued support of Higuchi Shokai. ▼Exhibited Products • Drug Screening & Toxicity Testing Organ-on-a-Chip • Organoid Culture Device