Notice of Participation in the "7th Regenerative Medicine EXPO Tokyo" from July 9 (Wednesday) to July 11 (Friday), 2025.

Strict control of particle size and distribution!

Continuous crystallization One-step operation (without seeding, without micronization) Precise control of natural nucleation Millifluidic tubular reactor Multipurpose device compatible with multiple crystallization modes Cooling crystallization Co-flow antisolvent crystallization Frontal antisolvent crystallization

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A lineup of cleaning devices, pyrogen removal tunnels, and filling/capping equipment!

We offer an "Integrated Solution for Lab Batches." We provide the "Robot Filling/Capping Machine" from Steriline, a long-established European manufacturer highly specialized in the production of complete lines for the aseptic processing of injectable drugs. Additionally, we have high-quality glass pharmaceutical vials manufactured by the Stevanato Group, which can be filled immediately. Furthermore, we also offer the plastic push-fit cap "RayDyLyo." 【Product Lineup】 ■ Robot Filling/Capping Machine ■ High-quality Glass Pharmaceutical Vials ■ New Standard for RayDyLyo Vial Capping *For more details, please download the PDF or feel free to contact us.

• Filling and bottling machines
• Other cleaning equipment
• Resin container

Achieving monitoring of both total particle count and total viable count! A hygienic design that meets customer demands.

The "SYFPAC DUO" is a new and revolutionary blow-fill-seal device that integrates the shaping, aseptic filling, and sealing of containers into a single automated operation. It is certified by all international regulatory agencies as an advanced aseptic technology and complies with EU GMP Annex 1. Under Grade A conditions, containers are shaped and filled within a closed system, ensuring high safety while always being protected from the external environment. 【Features】 ■ Flexibility ■ Efficiency and sustainability ■ Insertion technology ■ Hygienic design ■ Low-temperature production *For more details, please download the PDF or feel free to contact us.

• Sealing machine

Innovation that offers diverse benefits! Simplifying the capping process.

"RayDyLyo" is a cap that fits ISO 8362-1 vial containers. The stopper is pre-assembled into the product. It supports various packaging specifications such as bulk packaging, RTP, and nest configurations. It is suitable for clinical trials and small-scale production, enabling the filling of pharmaceutical liquids and capping in sterile areas. Additionally, it features a simple push-only capping process. 【Features】 ■ Innovation that provides a variety of benefits ■ Simplified capping operations ■ Anti-counterfeiting measures ■ Differentiation from competitor products *For more details, please download the PDF or feel free to contact us.

• Plastic utensils and containers

"Do not plug! Sterile! Completely sealed!" Provided sterilized. This is a vial that can be filled immediately. Available in a wide range of variations from 1ml to 50ml.

We sell "Aseptic Resin Vials" (AT-Closed Vial). Product Name: AT-Closed Vial Manufacturer: Aseptic Technologies (Belgium) 【Features】 ● Resistant to extremely low temperatures (-196°C). ● No need for screwing operations. ● Process completed in three steps, including laser irradiation, which avoids contamination risks by omitting unnecessary tasks. ● High transparency. These vials are molded in an ISO 5 clean room and shipped in RTU condition through gamma irradiation. For the liquid-contacting parts, the body is made of COC (Cyclic Olefin Copolymer), and the rubber stopper uses patented TPE (Thermoplastic Elastomer).

• Filling and bottling machines

Ampoule, vial, syringe liquid and powder filling machine

The filling machines from the German company Rota are equipped with various devices as part of a complete line (such as for ampoules, vials, syringes, and bottles). We also offer individual models for washing machines, sterilizers, filling machines, capping machines, labeling machines, and inspection machines.

• Filling and bottling machines

Prefilled syringe, eye drops, bottle container

BFS (Blow-Fill-Seal Technology) is mainly used for aseptic formulations and is applied in the packaging of injectables, antibiotics, eye drops, suspensions, infusions, dialysis solutions, cleaning solutions, and blood filtration solutions. In addition to these main areas, this technology can also be utilized for packaging various cosmetics, including creams, fresh juices, non-carbonated beverages, and milk.

• Filling and bottling machines

• Suspended particles in liquid • Weight particles • Product liquid level • Defects in the appearance and functionality of the container • Leak testing The above can be implemented.

The LYNX device, developed for handling LVPs (large volume parenterals) and infusion bottles, provides an ideal solution to inherently eliminate foreign substances that affect the sterility of the product, as well as aesthetic and functional defects of other containers.

• Other inspection equipment and devices

It is a liquid filling device suitable for small-scale production such as trial research.

It is a compact robot nest filling machine made by the Italian company Steriline, designed for installation in small spaces.

• Contract manufacturing

This is a sterilization device suitable for small-scale production in development and prototype research.

- Can be installed in an ISO8 environment. - Compact and lightweight compared to general EB sterilization devices, allowing for installation in small spaces. - Pulse sterilization using xenon lamps achieves sterility assurance level (10^-6) by irradiating multiple times. Can sterilize two items (syringes, vials, cartridges, etc.) per minute.

• Contract manufacturing
• Sterilizer

The semi-automatic tablet press, which allows for easy operation and data recording, can be used anywhere and by any operator.

- No long setup time is required for small batch tablet pressing. - Fewer parts make maintenance easy. - The structure is simple, and the operability is excellent. Anyone can handle it. - By installing a dedicated electric hydraulic pump, stable tablet pressing and data collection and storage are possible. (Pressing force, tablet pressing time, etc.) - An additional feeder for double-layer tablet pressing can also be installed. - The main unit weighs 55 kilograms, making it relatively light and easy to place anywhere. Please check the actual operation and video from the link below! https://www.youtube.com/watch?v=hrlRrmRudgA

• Powder Molding Machine

This is a tablet press specialized for research and development, capable of recording detailed data from a variety of settings.

The FlexiTab XL tablet press is a tablet press specialized for research and development that can acquire a variety of data. In addition to [pressing force], [discharge pressure], and [pressurization time], it can also track [pressure changes], [position determination of the upper and lower punches], and [data for each layer]. Furthermore, it allows for the setting of nucleated tablet pressing using the [nucleated tablet feeder], tablet pressing with up to three types of powders through individual settings using the [multi-layer tablet powder feeder], and can measure the thickness of tablets in detail up to 0.015mm using a [dedicated gauge]. Not only can these data be recorded, but they can also be observed in real-time. There are still many features that can be set, so please feel free to contact us for more details. While there are many settings available, it can be operated very simply. For information on appearance and operation, please watch the video below. https://www.youtube.com/watch?v=cJyDXalQE9E

• Powder Molding Machine

Powder, tablet, granule, and liquid filling is possible! Numerous achievements in the field of small-scale production!

The tabletop fully automatic capsule filling machine IN-CAP has numerous achievements in recent years in the field of small-scale production for formulation development and prototype research at R&D laboratories, hospitals, and pharmacies of pharmaceutical manufacturers around the world. In addition to filling **powder**, it is also capable of filling **liquids**, **granules**, and **tablets**, and multiple unit combinations can be achieved in a single filling process. The powder filling method can be selected as either **tamping type** or **pick & press type**. The equipment is manufactured in compliance with CE and GMP standards. Upon request, we can also accommodate IQ/OQ validation and provide information on equipment suitable for handling highly active substances. For more details, please contact us or refer to the catalog.

• Other packaging machines

This is a filling machine ideal for small-scale pharmaceutical filling, with a capacity of up to 600 bottles per hour.

The "Crystal L1 Robot Line" is an experimental facility for closed vials. It is a sterile filling machine for liquid and non-oral freeze-dried products. It accommodates all product types, including cytotoxic and biohazard materials. It is ideal for filling clinical trial lots, product stability evaluation batches, clinical batches, and niche products. 【Specifications】 ○ Processing capacity (2ml vials): Up to 600 vials/hour ○ Filling volume: From 0.1ml to 50ml + overfill ○ Filling accuracy: +/-1% (for filling volumes under 1ml, +/-10μl) ○ Dimensions (mm): Overall length 1190 × width 760 × height 930 ○ Utilities: Electric only; water and compressed air are not required ○ Material: All contact (powder contact) parts are made of AISI316L For further details, please download the catalog or contact us.

• Filling and bottling machines
• Other laboratory equipment and containers

CBM Corporation - Import and Sales of Confectionery and Pharmaceutical Machinery

Since its establishment, CBM Corporation has served as an antenna for everyone, providing new information while ensuring that all employees undergo overseas training to acquire extensive knowledge and skills. We implement consistent customer service from sales to after-sales support. Currently, we have entered into agency agreements with dozens of excellent machinery manufacturers in various European countries, including the United States, the United Kingdom, Germany, Italy, Denmark, the Netherlands, and France, importing machinery for confectionery, pharmaceuticals, and food processing. In July 1996, in response to business expansion, we consolidated our sales and technical service departments to further facilitate communication with our clients and within the company. We will continue to strive to be a good partner for everyone and earn your continued support. For more details, please contact us or refer to our catalog.

• Food Processing Equipment
• Other food machinery
• Filling and bottling machines

Can be installed in a small space! The Flexicon PF7 peristaltic pump allows for small volume filling. The utility is only 100V electricity.

Filling, laser sealing, and capping necessary for the operation of AT closed vials can be performed in a small space.

• Other assembly machines

You can achieve blister packaging simply by forming the blister at the manufacturer and sealing it with your MAXIPACK.

PVC/ALU ALU/ALU, etc. Sealing is possible with this machine. Blister molding (= pre-blister) will be carried out by an Italian manufacturer.

• Other packaging machines

Easy operation with the push of a button. Please make use of it for research and development (R&D) and small lot production.

If you use a sheet that fits the mold size, you can easily perform blister packaging with just the push of a button! This simple and user-friendly blister/PTP packaging machine is suitable for research and development purposes. It can also produce PVC/ALU and ALU/ALU. Fantasy Plus comes with an HMI monitor, while the version without a monitor is called Fantasy ST.

• Other packaging machines

Infusion bag inspection machine using artificial intelligence (AI)

This is an infusion bag inspection machine centered around artificial intelligence. With AI and deep learning, it can inspect defects in particles and appearance with extreme accuracy, overcoming many past issues and the detection of incorrectly rejected products (such as bubbles, silk screen printing on containers, and aesthetic defects in seemingly unrelated containers). Thanks to its very compact design and flexible handling by robots, ROBOX has become a unique modular machine. This device allows for two types of visual inspection: manual inspection by an operator and automatic inspection using a camera equipped with artificial intelligence.

• Visual Inspection Equipment
• Defect Inspection Equipment

It is a filling and closing device suitable for research and development and for the production of small quantities of a wide variety of products.

It is the only multipurpose machine that combines the filling and closing of various containers with different characteristics, such as vials, syringes, eye drop bottles, nasal sprays, cartridges, diagnostic microtubes in nests, trays, and bulk.

• Pharmaceutical Packaging Machine

This is a German-made ampoule filling and sealing machine with excellent durability and expandability.

It is a filling and sealing machine with a wide range of scalability, from small batch to mass production.

• Filling and bottling machines

This is an isolator that is compact and easy to move, suitable for aseptic evaluation tests, efficiently achieving an ISO 5/Grade A environment.

The "QUBE" from Bioquell in the UK is a compactly designed modular isolator that can be easily expanded, disassembled, and moved according to your needs. By combining the basic hydrogen peroxide vapor generation module with expansion units and transport units, you can create a more user-friendly configuration tailored to your applications. The main body walls are made of high-durability polypropylene, and with a weight of 350 kg (for the gas dispersion module alone), it is lighter compared to other products and equipped with casters, allowing it to be moved by one person. Due to its modular design, delivery from order to shipment can be completed in a shorter time frame compared to other products.

• others

It comes with a rubber stopper already installed, allowing for capping with just a push.

• No metal used • The sealing is completed with a simple process of just pressing, no winding required • Compatible with widely distributed nested vials • Available in 11 colors

• Other bio-related product packaging materials and containers

Do not seal! Completely airtight! Provided sterilized. This is a closed vial that can be filled immediately.

【Features】 ● Made of COC, it has superior rigidity compared to glass. ● It is resistant to -196℃. ● It can be filled immediately, allowing for a reduction in pre-processing steps such as cleaning and sterilization. ● The cap and rubber stopper are integrated, eliminating the need for a tightening process. ● There are also proven records of use as final containers. It is molded in an ISO 5 clean room, sterilized with gamma rays, and provided in double bag packaging. For the liquid contact parts, COC (Cyclic Olefin Copolymer) is used for the main body, and TPE (Thermoplastic Elastomer) is used for the rubber stopper. 【When using the dedicated filling machine M1】 A laser is applied to the filling needle perforation area to weld the rubber stopper and ensure airtightness. * For details, please refer to the M1 Filling Station page.

• Filling and bottling machines

It is possible to manufacture cotton swabs in various shapes.

EURO B21 can produce adhesive agents, transdermal patches, and plasters, as well as bandages of various sizes. There are also various machines such as packaging machines.

• Other physicochemical equipment

Presenting materials! Introducing the final container that can be utilized in the field of regenerative medicine.

We provide an explanation of the AT-Closed Vials we handle, complete with images and illustrations. We are currently offering "A New Approach to Solving Challenges in Regenerative Medicine: Introduction to the AT-Closed Vial for Aseptic Filling Vol. 1" for free. Recommended for: ▮ Those looking for containers that can withstand low-temperature environments and liquid nitrogen ▮ Those searching for alternatives to glass vials ▮ Those who want to omit the sterilization, cleaning, and cap tightening processes etc. *For more details, please refer to the PDF document or feel free to contact us.

• Plastic utensils and containers

Compact and portable, suitable for R&D and small-scale production.

A practical and compact innovative blister machine, Fantasy. The three processes of forming, sealing, and cutting can all be executed by this machine without relying on wrenches or specialists, simply by exchanging parts related to the format. We can develop customized projects based on the actual needs of our customers and create tailor-made molds for the dimensions, configuration, and quantity of the blisters. The high-precision equipment installed in the machine enables electrical and electronic management, allowing for the production of high-quality blisters.

• Other packaging machines

It is an isolator that is compact and easy to move, achieving ISO 5/Grade A environment.

It is a compactly designed modular isolator that can be expanded, disassembled, and moved according to your needs. - Decontamination inside the chamber is completed in about 30 to 40 minutes using hydrogen peroxide vapor. - The main body walls are made of polypropylene, and with a weight of 350 kg, it is lightweight and equipped with casters, making it possible for one person to move it. - Acrylic windows. - Delivery is possible within 4 to 5 months from the order.

• isolator

We will be exhibiting at the "12th Conference of the Advanced Power Semiconductor Subcommittee" held at the Toyama International Conference Center. We will be introducing our latest analysis technology services, so please stop by! We sincerely look forward to your visit.

Our company will exhibit at the Measurement and Measurement Comprehensive Technology Exhibition in Hokuriku, showcasing safety products with Gemba Reporter. Please be sure to stop by booth number "72" when you visit. 【Date and Time】 November 6, 2025 (Thursday) 9:00 AM - 5:00 PM 【Venue】 Ishikawa Industrial Exhibition Hall, Building 2 From JR Kanazawa Station, take the Hokutetsu Bus bound for "Shimo-Yasuhara" and get off at "Fukurobatake Town West Green Park," then walk for 5 minutes. Alternatively, take the Hokutetsu Bus bound for "Saiseikai Hospital," get off at "Seibu Green Park," and it will take about 15 minutes by taxi. 【Materials】 https://www.line.co.jp/wp-content/uploads/2025/10/MepTechhokuriku2025.pdf 【Notes】 Please register in advance using the 2D barcode in the PDF.

Sekiguchi Iron Works Co., Ltd. will exhibit at the "Environmental Industry Expo 2025" held at S-Bird in Iida City, Nagano Prefecture. This exhibition aims to pave the way for a sustainable future from the local community. It is a trade fair for environmental-related industries originating from the Minami-Shinshu region of Nagano Prefecture. Our company will introduce next-generation solutions for reducing environmental impact and effectively utilizing energy, including our "smokeless small incinerator" and "stove," along with product panels and case studies. No pre-registration is required, and admission is free. We sincerely look forward to your visit.

Recently, fine bubbles, which are tiny bubbles smaller than 100 μm and are referred to as "fine bubbles," have attracted attention in various fields such as the environment, agriculture, food, fisheries, and medicine, due to their ability to impart various functions to liquids. Fine bubbles are classified into two types based on their size: microbubbles and ultrafine bubbles. Recently, there has been a growing interest in ultrafine bubbles, which have a lifespan of several weeks to months. However, listening to the voices of researchers and users reveals some skepticism, which has become one of the issues hindering the spread of fine bubble technology. On the other hand, we have challenged the elucidation of the stabilization mechanism of ultrafine bubbles from a new perspective by enabling the control of number density exceeding 10 billion particles/mL without pressure or concentration operations using our ultrafine bubble generation technology. In this seminar, we will provide a fundamental explanation of fine bubble technology, including the basic physical properties, characteristics and functions, device technology, measurement and evaluation methods, and case studies, to promote research and utilization of fine bubbles based on a correct understanding.

Sekiguchi Iron Works Co., Ltd. will exhibit at the "Minami-Shinshu Environmental Messe 2025" held at S-Bird in Iida City, Nagano Prefecture. This exhibition will be held simultaneously with the "Environmental Industry Trade Fair" taking place the day before. It will be held over the weekend, with many family-friendly events planned. We encourage those who usually find it difficult to visit to take this opportunity to come. Our product exhibition area is located about 10 minutes from the venue. We sincerely look forward to your visit.