Notice of Participation in the "7th Regenerative Medicine EXPO Tokyo" from July 9 (Wednesday) to July 11 (Friday), 2025.

Strict control of particle size and distribution!

Continuous crystallization One-step operation (without seeding, without micronization) Precise control of natural nucleation Millifluidic tubular reactor Multipurpose device compatible with multiple crystallization modes Cooling crystallization Co-flow antisolvent crystallization Frontal antisolvent crystallization

• crystal

A lineup of cleaning devices, pyrogen removal tunnels, and filling/capping equipment!

We offer an "Integrated Solution for Lab Batches." We provide the "Robot Filling/Capping Machine" from Steriline, a long-established European manufacturer highly specialized in the production of complete lines for the aseptic processing of injectable drugs. Additionally, we have high-quality glass pharmaceutical vials manufactured by the Stevanato Group, which can be filled immediately. Furthermore, we also offer the plastic push-fit cap "RayDyLyo." 【Product Lineup】 ■ Robot Filling/Capping Machine ■ High-quality Glass Pharmaceutical Vials ■ New Standard for RayDyLyo Vial Capping *For more details, please download the PDF or feel free to contact us.

• Filling and bottling machines
• Other cleaning equipment
• Resin container

Achieving monitoring of both total particle count and total viable count! A hygienic design that meets customer demands.

The "SYFPAC DUO" is a new and revolutionary blow-fill-seal device that integrates the shaping, aseptic filling, and sealing of containers into a single automated operation. It is certified by all international regulatory agencies as an advanced aseptic technology and complies with EU GMP Annex 1. Under Grade A conditions, containers are shaped and filled within a closed system, ensuring high safety while always being protected from the external environment. 【Features】 ■ Flexibility ■ Efficiency and sustainability ■ Insertion technology ■ Hygienic design ■ Low-temperature production *For more details, please download the PDF or feel free to contact us.

• Sealing machine

Innovation that offers diverse benefits! Simplifying the capping process.

"RayDyLyo" is a cap that fits ISO 8362-1 vial containers. The stopper is pre-assembled into the product. It supports various packaging specifications such as bulk packaging, RTP, and nest configurations. It is suitable for clinical trials and small-scale production, enabling the filling of pharmaceutical liquids and capping in sterile areas. Additionally, it features a simple push-only capping process. 【Features】 ■ Innovation that provides a variety of benefits ■ Simplified capping operations ■ Anti-counterfeiting measures ■ Differentiation from competitor products *For more details, please download the PDF or feel free to contact us.

• Plastic utensils and containers

"Do not plug! Sterile! Completely sealed!" Provided sterilized. This is a vial that can be filled immediately. Available in a wide range of variations from 1ml to 50ml.

We sell "Aseptic Resin Vials" (AT-Closed Vial). Product Name: AT-Closed Vial Manufacturer: Aseptic Technologies (Belgium) 【Features】 ● Resistant to extremely low temperatures (-196°C). ● No need for screwing operations. ● Process completed in three steps, including laser irradiation, which avoids contamination risks by omitting unnecessary tasks. ● High transparency. These vials are molded in an ISO 5 clean room and shipped in RTU condition through gamma irradiation. For the liquid-contacting parts, the body is made of COC (Cyclic Olefin Copolymer), and the rubber stopper uses patented TPE (Thermoplastic Elastomer).

• Filling and bottling machines

Ampoule, vial, syringe liquid and powder filling machine

The filling machines from the German company Rota are equipped with various devices as part of a complete line (such as for ampoules, vials, syringes, and bottles). We also offer individual models for washing machines, sterilizers, filling machines, capping machines, labeling machines, and inspection machines.

• Filling and bottling machines

Prefilled syringe, eye drops, bottle container

BFS (Blow-Fill-Seal Technology) is mainly used for aseptic formulations and is applied in the packaging of injectables, antibiotics, eye drops, suspensions, infusions, dialysis solutions, cleaning solutions, and blood filtration solutions. In addition to these main areas, this technology can also be utilized for packaging various cosmetics, including creams, fresh juices, non-carbonated beverages, and milk.

• Filling and bottling machines

• Suspended particles in liquid • Weight particles • Product liquid level • Defects in the appearance and functionality of the container • Leak testing The above can be implemented.

The LYNX device, developed for handling LVPs (large volume parenterals) and infusion bottles, provides an ideal solution to inherently eliminate foreign substances that affect the sterility of the product, as well as aesthetic and functional defects of other containers.

• Other inspection equipment and devices

Syringe cartridge inspection machine

The A&V GS device, developed for handling syringes and cartridges, provides an ideal solution to inherently eliminate foreign substances that affect the sterility of non-oral administration products, as well as aesthetic and functional defects of other containers.

• Other inspection equipment and devices

Foreign Matter Inspection Device in Liquid ◆ Ampoule ◆ Vial ◆ Cartridge ◆ Prefilled Syringe

We will conduct the following inspections using LED lights and a high-resolution camera! - Foreign matter inspection in liquid - Appearance inspection - Foreign matter inspection - Leak inspection

• Other inspection equipment and devices

It is a liquid filling device suitable for small-scale production such as trial research.

It is a compact robot nest filling machine made by the Italian company Steriline, designed for installation in small spaces.

• Contract manufacturing

This is a sterilization device suitable for small-scale production in development and prototype research.

- Can be installed in an ISO8 environment. - Compact and lightweight compared to general EB sterilization devices, allowing for installation in small spaces. - Pulse sterilization using xenon lamps achieves sterility assurance level (10^-6) by irradiating multiple times. Can sterilize two items (syringes, vials, cartridges, etc.) per minute.

• Contract manufacturing
• Sterilizer

The semi-automatic tablet press, which allows for easy operation and data recording, can be used anywhere and by any operator.

- No long setup time is required for small batch tablet pressing. - Fewer parts make maintenance easy. - The structure is simple, and the operability is excellent. Anyone can handle it. - By installing a dedicated electric hydraulic pump, stable tablet pressing and data collection and storage are possible. (Pressing force, tablet pressing time, etc.) - An additional feeder for double-layer tablet pressing can also be installed. - The main unit weighs 55 kilograms, making it relatively light and easy to place anywhere. Please check the actual operation and video from the link below! https://www.youtube.com/watch?v=hrlRrmRudgA

• Powder Molding Machine

This is a tablet press specialized for research and development, capable of recording detailed data from a variety of settings.

The FlexiTab XL tablet press is a tablet press specialized for research and development that can acquire a variety of data. In addition to [pressing force], [discharge pressure], and [pressurization time], it can also track [pressure changes], [position determination of the upper and lower punches], and [data for each layer]. Furthermore, it allows for the setting of nucleated tablet pressing using the [nucleated tablet feeder], tablet pressing with up to three types of powders through individual settings using the [multi-layer tablet powder feeder], and can measure the thickness of tablets in detail up to 0.015mm using a [dedicated gauge]. Not only can these data be recorded, but they can also be observed in real-time. There are still many features that can be set, so please feel free to contact us for more details. While there are many settings available, it can be operated very simply. For information on appearance and operation, please watch the video below. https://www.youtube.com/watch?v=cJyDXalQE9E

• Powder Molding Machine

Powder, tablet, granule, and liquid filling is possible! Numerous achievements in the field of small-scale production!

The tabletop fully automatic capsule filling machine IN-CAP has numerous achievements in recent years in the field of small-scale production for formulation development and prototype research at R&D laboratories, hospitals, and pharmacies of pharmaceutical manufacturers around the world. In addition to filling **powder**, it is also capable of filling **liquids**, **granules**, and **tablets**, and multiple unit combinations can be achieved in a single filling process. The powder filling method can be selected as either **tamping type** or **pick & press type**. The equipment is manufactured in compliance with CE and GMP standards. Upon request, we can also accommodate IQ/OQ validation and provide information on equipment suitable for handling highly active substances. For more details, please contact us or refer to the catalog.

• Other packaging machines

This is a filling machine ideal for small-scale pharmaceutical filling, with a capacity of up to 600 bottles per hour.

The "Crystal L1 Robot Line" is an experimental facility for closed vials. It is a sterile filling machine for liquid and non-oral freeze-dried products. It accommodates all product types, including cytotoxic and biohazard materials. It is ideal for filling clinical trial lots, product stability evaluation batches, clinical batches, and niche products. 【Specifications】 ○ Processing capacity (2ml vials): Up to 600 vials/hour ○ Filling volume: From 0.1ml to 50ml + overfill ○ Filling accuracy: +/-1% (for filling volumes under 1ml, +/-10μl) ○ Dimensions (mm): Overall length 1190 × width 760 × height 930 ○ Utilities: Electric only; water and compressed air are not required ○ Material: All contact (powder contact) parts are made of AISI316L For further details, please download the catalog or contact us.

• Filling and bottling machines
• Other laboratory equipment and containers

CBM Corporation - Import and Sales of Confectionery and Pharmaceutical Machinery

Since its establishment, CBM Corporation has served as an antenna for everyone, providing new information while ensuring that all employees undergo overseas training to acquire extensive knowledge and skills. We implement consistent customer service from sales to after-sales support. Currently, we have entered into agency agreements with dozens of excellent machinery manufacturers in various European countries, including the United States, the United Kingdom, Germany, Italy, Denmark, the Netherlands, and France, importing machinery for confectionery, pharmaceuticals, and food processing. In July 1996, in response to business expansion, we consolidated our sales and technical service departments to further facilitate communication with our clients and within the company. We will continue to strive to be a good partner for everyone and earn your continued support. For more details, please contact us or refer to our catalog.

• Food Processing Equipment
• Other food machinery
• Filling and bottling machines

Can be installed in a small space! The Flexicon PF7 peristaltic pump allows for small volume filling. The utility is only 100V electricity.

Filling, laser sealing, and capping necessary for the operation of AT closed vials can be performed in a small space.

• Other assembly machines

You can achieve blister packaging simply by forming the blister at the manufacturer and sealing it with your MAXIPACK.

PVC/ALU ALU/ALU, etc. Sealing is possible with this machine. Blister molding (= pre-blister) will be carried out by an Italian manufacturer.

• Other packaging machines

Easy operation with the push of a button. Please make use of it for research and development (R&D) and small lot production.

If you use a sheet that fits the mold size, you can easily perform blister packaging with just the push of a button! This simple and user-friendly blister/PTP packaging machine is suitable for research and development purposes. It can also produce PVC/ALU and ALU/ALU. Fantasy Plus comes with an HMI monitor, while the version without a monitor is called Fantasy ST.

• Other packaging machines

Infusion bag inspection machine using artificial intelligence (AI)

This is an infusion bag inspection machine centered around artificial intelligence. With AI and deep learning, it can inspect defects in particles and appearance with extreme accuracy, overcoming many past issues and the detection of incorrectly rejected products (such as bubbles, silk screen printing on containers, and aesthetic defects in seemingly unrelated containers). Thanks to its very compact design and flexible handling by robots, ROBOX has become a unique modular machine. This device allows for two types of visual inspection: manual inspection by an operator and automatic inspection using a camera equipped with artificial intelligence.

• Visual Inspection Equipment
• Defect Inspection Equipment

It is a filling and closing device suitable for research and development and for the production of small quantities of a wide variety of products.

It is the only multipurpose machine that combines the filling and closing of various containers with different characteristics, such as vials, syringes, eye drop bottles, nasal sprays, cartridges, diagnostic microtubes in nests, trays, and bulk.

• Pharmaceutical Packaging Machine

This is a German-made ampoule filling and sealing machine with excellent durability and expandability.

It is a filling and sealing machine with a wide range of scalability, from small batch to mass production.

• Filling and bottling machines

This is an isolator that is compact and easy to move, suitable for aseptic evaluation tests, efficiently achieving an ISO 5/Grade A environment.

The "QUBE" from Bioquell in the UK is a compactly designed modular isolator that can be easily expanded, disassembled, and moved according to your needs. By combining the basic hydrogen peroxide vapor generation module with expansion units and transport units, you can create a more user-friendly configuration tailored to your applications. The main body walls are made of high-durability polypropylene, and with a weight of 350 kg (for the gas dispersion module alone), it is lighter compared to other products and equipped with casters, allowing it to be moved by one person. Due to its modular design, delivery from order to shipment can be completed in a shorter time frame compared to other products.

• others

It comes with a rubber stopper already installed, allowing for capping with just a push.

• No metal used • The sealing is completed with a simple process of just pressing, no winding required • Compatible with widely distributed nested vials • Available in 11 colors

• Other bio-related product packaging materials and containers

Do not seal! Completely airtight! Provided sterilized. This is a closed vial that can be filled immediately.

【Features】 ● Made of COC, it has superior rigidity compared to glass. ● It is resistant to -196℃. ● It can be filled immediately, allowing for a reduction in pre-processing steps such as cleaning and sterilization. ● The cap and rubber stopper are integrated, eliminating the need for a tightening process. ● There are also proven records of use as final containers. It is molded in an ISO 5 clean room, sterilized with gamma rays, and provided in double bag packaging. For the liquid contact parts, COC (Cyclic Olefin Copolymer) is used for the main body, and TPE (Thermoplastic Elastomer) is used for the rubber stopper. 【When using the dedicated filling machine M1】 A laser is applied to the filling needle perforation area to weld the rubber stopper and ensure airtightness. * For details, please refer to the M1 Filling Station page.

• Filling and bottling machines

It is possible to manufacture cotton swabs in various shapes.

EURO B21 can produce adhesive agents, transdermal patches, and plasters, as well as bandages of various sizes. There are also various machines such as packaging machines.

• Other physicochemical equipment

Presenting materials! Introducing the final container that can be utilized in the field of regenerative medicine.

We provide an explanation of the AT-Closed Vials we handle, complete with images and illustrations. We are currently offering "A New Approach to Solving Challenges in Regenerative Medicine: Introduction to the AT-Closed Vial for Aseptic Filling Vol. 1" for free. Recommended for: ▮ Those looking for containers that can withstand low-temperature environments and liquid nitrogen ▮ Those searching for alternatives to glass vials ▮ Those who want to omit the sterilization, cleaning, and cap tightening processes etc. *For more details, please refer to the PDF document or feel free to contact us.

• Plastic utensils and containers

Compact and portable, suitable for R&D and small-scale production.

A practical and compact innovative blister machine, Fantasy. The three processes of forming, sealing, and cutting can all be executed by this machine without relying on wrenches or specialists, simply by exchanging parts related to the format. We can develop customized projects based on the actual needs of our customers and create tailor-made molds for the dimensions, configuration, and quantity of the blisters. The high-precision equipment installed in the machine enables electrical and electronic management, allowing for the production of high-quality blisters.

• Other packaging machines

It is an isolator that is compact and easy to move, achieving ISO 5/Grade A environment.

It is a compactly designed modular isolator that can be expanded, disassembled, and moved according to your needs. - Decontamination inside the chamber is completed in about 30 to 40 minutes using hydrogen peroxide vapor. - The main body walls are made of polypropylene, and with a weight of 350 kg, it is lightweight and equipped with casters, making it possible for one person to move it. - Acrylic windows. - Delivery is possible within 4 to 5 months from the order.

• isolator

Nitto Kohki will hold the "2024 Attack Fair in Ichihara" at the "Yume Hall" for two days from December 11 (Wednesday) to December 12 (Thursday), 2024. The Attack Fair is an exhibition where you can actually "see, touch, and operate" Nitto Kohki's products. Additionally, there will be wonderful souvenirs for visitors and many fun activities prepared. We look forward to welcoming everyone!

Nitto Kohki will hold the "2025 Attack Fair in Kurume" at the "Local Production Kurume General Exhibition Hall" for two days from February 13 (Thursday) to February 14 (Friday), 2025. The Attack Fair is an exhibition where you can actually "see, touch, and operate" Nitto Kohki's products. Additionally, there will be wonderful commemorative gifts for visitors and many fun activities prepared. We look forward to welcoming everyone!

**Seminar Overview** The construction industry faces many challenges, including a shortage of personnel, regulations on maximum working hours, and the need for efficiency improvements. Additionally, the transmission of skills due to an aging workforce has become a significant issue, with a high turnover rate among younger employees who are supposed to carry on these skills. In this seminar, we will discuss the causes of turnover based on case studies and explain key points on how to reduce turnover rates by advancing IT integration.

**Seminar Overview** "Generative AI," which is gaining attention as a method for improving business efficiency and utilizing internal digital transformation (DX), can be influenced by the literacy of the employees using it, potentially increasing the burden of work instead. In this seminar, we will discuss the current challenges of generative AI while providing examples of how it can be used to enhance business efficiency. We will also explain how to utilize generative AI in a way that achieves efficiency without being dependent on the user's skills. We hope this will serve as a reference for considering the use of generative AI.

**Seminar Overview** The reality that young members leave their jobs due to miscommunication with their superiors occurs in every industry. This is also true in the construction industry. The long-standing issues of labor shortages, regulations on working hours, and the challenges of passing on skills due to an aging workforce are significant problems. However, the misalignment in communication with young employees, who are supposed to be receiving this knowledge, may actually worsen the situation. In this seminar, we will discuss the causes of communication gaps as seen through case studies, and talk about methods for skill transfer, knowledge accumulation, and smooth internal communication using IT tools.