Notice of Exhibition at the 54th Annual Meeting of the Japanese Society of Environmental Mutagenesis and Genomics

Toxicity prediction from compound structural information! - Compliant with ICH M7 guidelines for food health impact assessment -

It is a type of "Quantitative Structure-Activity Relationship (QSAR)" software developed in collaboration between MultiCASE and the FDA/CDER, which predicts toxicity from the 2D structural information of compounds. CASE Ultra has two complementary types of (Q)SAR models: knowledge (rule)-based and statistical-based, and it is capable of complying with ICH M7. Additionally, it allows for the creation of new predictive models using proprietary data and the enhancement of existing predictive models. 【Features】 ■ Joint research and development with FDA/CDER ■ Alternative to cell tests and animal experiments ■ Provides analogs based on alert surrounding structural environments ■ Supports expert judgment ■ Lead across 【Predictable Endpoints】 - Mutagenicity - Genotoxicity - Carcinogenicity - Hepatotoxicity - Nephrotoxicity - Cardiotoxicity - Dermal and ocular toxicity - Reproductive and developmental toxicity - Acute toxicity - Ecotoxicity - Endocrine receptor binding and many more.

• Other research software

Search all databases and literature information worldwide at once!

ToxPlanet is an integrated search platform that encompasses toxicity and hazard information for chemical substances. It features an intuitive interface and covers information on over 110 million compounds from more than 1,300 data collections, over 700 regulatory and advisory lists, and more than 10 million literature references. By obtaining comprehensive toxicity and hazard information for chemical substances from a single search key, it reduces investigation time and workload in safety research and risk assessment tasks, while enhancing the quality of the investigation.

• Other research software

It is possible to evaluate the acceptable intake levels of nitroamines and predict nitrosation.

QSAR Flex enables the prediction of complex toxicity using quantitative structure-activity relationships (QSAR) and read-across methods. In particular, the following models can be utilized to support the carcinogenicity assessment of nitrosamines: - Support for AI value evaluation based on CPCA - Support for AI value estimation through read-across - Prediction of nitrosamine generation from compounds and synthetic pathways Various methods for evaluating nitrosamines can be conducted solely with QSAR Flex.

• Other research software

More innovatively! A platform built by scientists for scientists.

"Labstep" is a user-friendly and flexible electronic lab notebook (ELN) that captures all research-related data and metadata in real-time. It provides the capture and analysis of structured data in a safe and collaborative environment, supporting the creation and protection of intellectual property by research and development labs. By utilizing an open API, it allows for digital connections with instruments, devices, and systems, enabling direct integration into experimental records. 【Features】 ■ Modern and easy to use ■ User-friendly and flexible utilization ■ Provides capture and analysis of structured data in a safe and collaborative environment ■ Supports the creation and protection of intellectual property by research and development labs ■ Allows for centralized management of all experimental notes, protocols, samples, inventory, devices, and order management.

• Other quality control systems

Kanadebia Co., Ltd. will be exhibiting at the "9th Railway Technology Exhibition 2025 Mass-Trans Innovation Japan 2025" held at Makuhari Messe. This exhibition has been held since 2010 as a comprehensive trade fair where various railway-related technologies, including railway and transportation systems, infrastructure technology, facilities, power, transportation, operation management, vehicles, interiors, and passenger services, come together. Please be sure to check out the "Railway Camera System" offered by Kanadebia. We sincerely look forward to your visit.

On November 20, 2025 (Thursday) and December 2, 2025 (Tuesday) from 11:00 to 14:00, our representative, certified public accountant and tax accountant Koichi Yokoyama, will be speaking at a free webinar hosted by Otsuka Shokai. He will explain important points to be aware of regarding the revised Construction Industry Law. [Construction Industry Law / Public Works Appropriateness Promotion Law] - Prevention of omissions in the description of construction contracts - Obligation to notify "risk" information before the contractor's contract - Mutual exchange of original documents for construction contracts - Digitization of estimates, contracts, and order forms/acceptance letters We are entering an era where contracts must be documented in writing and stored electronically. At Paperlogic, we fully support companies that are transitioning from paper to digital. We also offer free consultations with certified public accountants and tax accountants, so please join us!

We would like to inform you that we will be exhibiting our products at the Membrane Symposium 2025. If you are planning to attend, please feel free to stop by. ❚ Products Scheduled for Exhibition - Artificial Lipid Bilayer Experimental Device | Orbit mini You can easily measure channel activity at the single-molecule level. This device allows for the formation of lipid membranes, reconstitution of membrane proteins, and single-channel measurements in experiments using artificial lipid bilayers, all performed with just a micropipette, enabling functional and structural analysis of target membrane proteins and evaluation of drug effects. - Liposome Preparation Device | Vesicle Prep Pro This is the world's first device that can produce giant unilamellar vesicles (GUVs) with diameters ranging from 1 to 30 μm without organic solvents, using the electroporation method (vibrating hydrated lipid films in an alternating electric field). - Auto Patch Clamp System | Port-a-Patch mini This compact system eliminates the need for a microscope, vibration isolation table, manipulator, and Faraday cage, which are typically required for conventional patch clamp experiments. It allows for easy data acquisition and verification without the need for specialized skills or experience.

Agilent will be exhibiting at the "VACUUM 2025 Vacuum Exhibition"! At Agilent, we offer clean and quiet IDP dry scroll pumps, high-performance and high-compression TwisTorr turbo pumps, ion pumps and controllers optimized for UHV/XHV, and robust and reliable helium leak detectors. Leveraging the technology and expertise cultivated at Varian Vacuum, we respond to our customers' vacuum needs with the value of our products and support based on extensive experience and knowledge. Agilent's pumps, systems, and components enable cutting-edge research in physics, analytical instruments, and nanotechnology, and are also ideal for industrial processes. We invite you to visit the Agilent booth! 【Exhibition Information】 Date: December 3 (Wed) - 5 (Fri), 2025, 10:00 - 17:00 Venue: Tokyo Big Sight, South Hall 2 Booth Number: V-36

＼ Make electrical design easier with comprehensive electrical design CAD Eplan! ／ At this exhibition, under the theme "Data collaboration from design to manufacturing! Significant reduction of lead time in control panel manufacturing through digitalization," we will introduce how Eplan and Rittal can enhance the efficiency of electrical design and control panel manufacturing. We will provide information that can assist you in all processes from design to manufacturing, including the efficiency and automation of electrical design and the manufacturing process of control panels utilizing digital twins. If you are struggling with electrical design or considering the introduction of electrical design CAD, please visit the Eplan and Rittal booth. Date: November 19 (Wed) to November 21 (Fri), 2025, 10:00 AM to 5:00 PM Venue: Tokyo Big Sight, East Hall 4, 4-05 Attendance at "IIFES 2025" requires complete advance registration, so please apply on the official exhibition website. "IIFES 2025" official website: https://iifes.jp/