[Sending Recorded Video] Services Offered by Sartorius - Introduction to Cell Line Development, Cell Banking, and Various Tests.

Using Cellca cell line development, over 120 projects have been successfully completed.

Zaltrius is a top provider of cell line development services. It offers cost-effective and highly reliable technology platforms. Cellca cell line development consistently delivers clones for stable research cells that have undergone sufficient characterization. From DNA to research cell banks (RCB) in just 14 weeks, it achieves a minimum monoclonal antibody titer of 5g/L with a scalable fed-batch process.

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Conducted safety and characterization analysis tests on over 200 Chinese hamster ovary (CHO) cell bank samples.

CHO cells are the most widely used production cell lines in the pharmaceutical industry, and their safety profile has been established for over 20 years. Guidelines for the safety and characterization analysis of CHO production cell lines are harmonized with the International Conference on Harmonisation (ICH) Q5 (R1) "Virus Safety Evaluation of Biotechnology Products Derived from Cell Lines of Human or Animal Origin" and ICH Q5D "Derivation, Characterization, and Production of Cell Lines for the Manufacture of Biological Products (Biotechnology-derived Products | Biologically-derived Products)." Since 2007, Sartorius has conducted safety and characterization testing for over 200 Chinese Hamster Ovary (CHO) cell bank samples. Our researchers possess extensive knowledge and experience and will provide advice on optimal and cost-effective testing strategies that comply with chemical and regulatory requirements. We will also consider the history of the cell lines and raw materials used during bank manufacturing when proposing test packages.

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Introducing comprehensive solutions for safety testing of biological products and viral vaccines.

All biological products must undergo rigorous safety testing at both the development and manufacturing stages to confirm the characteristics of the product and host cells, as well as to ensure non-contamination. ▪ Exceptional technical expertise ▪ Rapid result delivery ▪ Extensive regulatory knowledge ▪ Enhanced quality assurance

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Integrated services with expertise and industry leadership.

【Top Service Provider】 The foundation for the approval of new biopharmaceuticals is built on a robust analytical data package that demonstrates the safety, purity, and efficacy of the product. BioOutsource's analytical testing package combines physicochemical and biological analytical methods, allowing for detailed characterization tailored to each client. 【Client Management Organization】 Projects are carried out by cross-departmental teams, and client managers provide support and advice with high transparency throughout the entire lifecycle of the client's project. 【Industry-Leading Integrated Services】 By supporting the development and characterization of biopharmaceuticals from preclinical development to commercialization, we provide services tailored to our clients' needs.

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Next-generation GMP cell banking

Thorough characterization and documentation of similar master cell banks (MCB) and working cell banks (WCB) are crucial elements that lead to risk reduction and ensure the safety and product quality of all biologically derived products. An experienced team is leveraging CRO expertise to expand services such as cell bank manufacturing. ▪ Manufacturing in a closed system ▪ Quality assurance ▪ Integration into cell line development and biosafety services ▪ For your applications: from mAbs to vaccines

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Comprehensively supporting the early development of biopharmaceuticals on an independent platform.

Physical and Chemical, as well as Biological Equivalence of Biosimilars | Similarity Assessment 【Expertise】 Industry-leading experience with over 12 biosimilar molecules and more than 30 biosimilar development companies 【Speed to Market】 Cost-effective results guaranteed through a comprehensive lineup of ready-made assays for the characterization and equivalence | similarity assessment of biosimilars 【Higher Quality Assurance】 Providing the necessary data for submission at the time of application, backed by exceptional regulatory and industry insights

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The latest published paper utilized Abby. This will be an online seminar featuring Associate Professor Yosuke Katsuta from the Graduate School of Advanced Science and Technology, Kumamoto University, who is also a co-founder of StapleBio. He is working on RNA hacking technology development aimed at altering the higher-order structure of target mRNA using short nucleic acids named Staple nucleic acids, with the goal of controlling gene expression. He will present the latest data focusing on the results of cell experiments and animal experiments in the development of this technology. Related paper on the lecture content: "Staple oligomers induce a stable RNA G-quadruplex structure for protein translation inhibition in therapeutics" | Nature Biomedical Engineering

[Speaker] Yoshirō Tsuruhara, Representative of Auto Insight Inc. / Technology Journalist and Editor [Key Lecture Content] The global automotive industry is undergoing significant upheaval. The term "CAST," which is bringing about even greater changes than the previously used keyword "CASE," is at the forefront. It stands for four elements: "China," which has begun to lead global automotive technology; "AI" (Artificial Intelligence), which is transforming the development process; "SDV" (Software Defined Vehicle), which is revolutionizing the creation of vehicle value; and "Trump," which is altering the rules of the world. What does the future of the automotive industry look like with CAST? [Lecture Items] 1. Current state of the automotive industry 2. The keyword "CAST" symbolizing transformation and its meaning 3. How China is dismantling the old order of the automotive industry 4. Generative AI infiltrating all development processes 5. How SDV is transforming "value creation" in the automotive industry 6. How the second Trump administration will change the rules of the global automotive industry 7. Changes in how the automotive industry generates revenue 8. Q&A

[Lecture Items] 1. Energy-saving Project for Data Centers National Research and Development Agency New Energy and Industrial Technology Development Organization Next Generation Green Data Center Technology Development Project Project Manager Toshiyuki Ando 1. About NEDO 2. Overview of the Next Generation Green Data Center Technology Development Project 3. Future of Data Centers 4. Elements Necessary for Energy Saving 5. Overview of Research and Development 6. Q&A / Business Card Exchange 2. Technology Trends of GaN Power Devices Expected to Contribute to Energy Saving in Data Centers and Other Industrial Applications Professor Noriyuki Iwamuro, Tsukuba University, Mathematical and Physical Sciences 1. Current and Future of the Power Device Market 2. Key Points in Power Device Development 3. Technologies Supporting the Latest Silicon MOSFETs 4. Why GaN Devices for Data Centers 5. Latest Technologies of GaN Power Devices 6. Differentiation Between GaN and SiC Power Devices 7. Q&A / Business Card Exchange

This is an announcement for a seminar hosted by our group company, Jemco Japan Management Co., Ltd. ■ Theme: "Mastering 'DX that Can Be Used on the Ground'! Business Reform in Management and Indirect Departments Utilizing DX" ■ Date and Time: November 12, 2025 (Wednesday) 14:00–15:00 ■ Format: ZOOM Webinar 【Seminar Content】 1. The 2030 Problem and Productivity Challenges in Management Departments 2. An Overview of Business Reform Utilizing Digital Technology 3. Automation of Routine Tasks with RPA (Power Automate) 4. Knowledge Search and Document Utilization with Generative AI × RAG 5. Implementation Examples of "Small-Scale DX" with Power Apps 6. Development of DX Talent and Internal Deployment Models If you wish to participate in the seminar, please apply using the URL below. (You will be redirected to the group company's site) *Please apply early as the registration will close once capacity is reached. https://www.jemco.co.jp/seminar/20251112dx/?lfpeid=kqbONicaYDDx&lfmaid=1000360919-5

At our booth, we will propose products that enable "improved production efficiency" and "cost reduction" through the stabilization of plastic molding. In particular, for recycled plastics, which have been gaining importance recently, the representatives of each device will explain the test results verified with demo machines conducted in-house. We will have a demo unit of the polymer moisture meter "AquaTrack V," and customers who bring samples will be able to conduct actual measurements. Larger samples, such as preforms, can also be measured as they are. *Please inquire in advance about the types of samples. Additionally, we will present a booklet titled "Dr. Plastic Molding's Rheology Lecture Notes," summarizing the understanding of material properties and predictions of viscosity and flowability, to those we speak with at the booth. We sincerely look forward to your visit. ◎ Exhibition Contents - Polymer moisture meter "AquaTrack V" (actual machine on display; demo measurements available) - Ultra-compact polymer dehumidifying dryer "Card Series" (full-size mock-up on display) - Capillary rheometer "R6000" (panel on display)