Mammalian cultured cells and the genomes of all animals can be edited!
The "CRISPR/Cas9" system can edit the genomes of mammalian cultured cells and any animal. By simply preparing two components—a Cas9 nuclease capable of introducing double-strand breaks (DSB) in DNA and a gRNA that guides it to the target sequence—you can create gene mutation model animals in a short time. This system can also be used for animal species such as rats, which have been very difficult to create until now. 【Features】 ■ Capable of editing the genomes of mammalian cultured cells and any animal ■ Utilizes the acquired immune mechanism found in archaea ■ Can create gene mutation model animals in a short time ■ Usable for animal species such as rats, which have been difficult to create until now *For more details, please refer to the catalog or feel free to contact us.
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【Method of Production】 ■ We will provide a plasmid vector containing the Cas9 gene and guide RNA. ■ The adjusted plasmid DNA will be microinjected into fertilized eggs and implanted into pseudopregnant animals. ■ Founder candidate individuals will be born, raised, weaned, and biopsied. ■ Selection of mutant individuals (more than one) will be conducted using a surveyor assay. ■ Sequence analysis (optional) will be performed. ■ Delivery or breeding (separate estimate) will be conducted. *For more details, please refer to the catalog or feel free to contact us.
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For more details, please refer to the catalog or feel free to contact us.
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Special Immunology Research Institute Co., Ltd. has been providing in vitro diagnostic pharmaceuticals, monoclonal antibodies, and research reagents to basic researchers, clinicians, and laboratory personnel since its establishment. Our products are used not only in Japan but also by medical institutions in various countries, including Europe and the United States. Additionally, we also accept contract development for antibodies and measurement systems that are not included in our product line, so please feel free to consult us.