This is a probe-type near-infrared spectroscopy PAT tool. It can be used in various processes such as granulation, mixing, tableting, and coating.
This is an analytical device for inline and real-time monitoring of solid dosage form processes (mixing, granulation, drying, and tableting). It is installed at various points in the manufacturing process to analyze physical and chemical parameters. The hardware consists of a maximum of 4-channel NIR detection units and probes connected by optical fibers and cables. The software is a proven package that meets the specifications required for pharmaceutical manufacturing processes, including audit trail functionality, user management, and output of inspection results. We provide a complete PAT solution, as well as customized solutions tailored to customer requests.
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basic information
●Technology: Multiplex Diode Array Spectrometer ●Measurement Channels: x4 ●Wavelength Range: 1100-2200nm (Specification range 1150 - 2150nm) ●Wavelength Accuracy: ±1nm (Specification range 1150 - 2150nm) ●Communication: Ethernet (OPC, TCP/IP, SiPAT) ●Housing: Smooth surface compliant with GmP. IP65 / NEMA4 ●Dimensions: 160 x 220 x 240mm ●SentroProbe: Spot size Φ5mm / Surface 20mm² ●Light Source: Built-in dual 5W bulbs ●Built-in Reference: Integrated micro-mechanical white reference ●Process Window: Sapphire glass window ●Probe Shaft: Φ3/4" (19mm), available lengths 65, 100, 200, 300, 500mm ●Approval: ATEX Directive 20/21, CE ●Self-Monitoring: Built-in controller monitors probe functionality and status with sensors ●Operating Environment: Probe tip: 0° ... 80°C ●CIP Process: Up to 150°C
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Applications/Examples of results
It is used in various processes for manufacturing solid pharmaceutical formulations (material feeding feeder section, granulation, mixing, tableting, coating, capsule filling, etc.). Recently, the introduction of PAT into continuous manufacturing processes has been actively considered, expanding its range of applications.
Detailed information
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Installation on the forging process It is installed on the upper part of the forging paddle for monitoring.
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Heating function of the probe tip The heating function of the probe tip suppresses the adhesion of granulated powder.
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Company information
P.I.E Co., Ltd. is the exclusive distributor in Japan for Sentronic GmbH, based in Dresden, Germany. We provide everything from product demonstrations to IQ/OQ and after-sales maintenance. We promote Process Analytical Technology (PAT) using near-infrared (NIR) spectroscopy and support the realization of Quality by Design (QbD). Founded in 1993 in Dresden, Germany, Sentronic consists of two divisions: spectroscopy and optical sensors. The spectroscopy division offers various customer-specific industrial solutions based on NIR and UV/VIS spectral technologies. Sentronic is a system integrator that provides PAT solutions to pharmaceutical, chemical, and food factories. All aspects from product development and manufacturing to software development are conducted in-house. Custom system development tailored to customer requirements is also possible.