The human tumor cell line panel is a contract analysis service for compounds based on the proliferation of cell lines. We provide analysis results that are useful for cancer drug discovery.
The human tumor cell line panel "Oncolines" is a compound profiling based on the proliferation of cell lines. It allows for the analysis of the effects of compounds on diverse tissue-derived cell lines, combined with information on genetic mutations. The full panel usage includes the "Oncolines Profiler," which analyzes how your compounds exhibit similar cell proliferation inhibition to existing drugs, at no charge. 【Features】 ■ Currently holds 102 types of cell lines ■ Analysis possible in combination with genetic mutation information ■ Cultured in media recommended by ATCC ■ Licensed by ATCC, one of the world's largest cell banks For follow-up, please use the drug combination effect analysis service "SynergyFinder," which analyzes synergistic effects through combinations with existing drugs. 【Features】 ■ Analyzes the synergistic effects of combined compounds, distinguishing them from additive effects ■ Can be combined with over 120 existing drugs that have been pre-profiled
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basic information
Oncolines Assay Method Seed cell lines in a 384-well plate and culture for 24 hours, then add compounds and continue to culture for 72 hours in the presence of the compounds. Measure cell proliferation using ATP levels as an indicator. The test concentrations are conducted at 9 concentrations (half-log) in duplicate, and IC50, GI50, and LD50 values are calculated from the inhibition curve. *For more details, please refer to the catalog or feel free to contact us.*
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For more details, please refer to the catalog or feel free to contact us.
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Company information
Kinase Company and Karuna Biosciences continue to develop and pursue their proprietary kinase core technology, which we provide as a drug discovery support service to assist researchers at pharmaceutical companies and academic institutions. Our kinase protein products, boasting world-class quality and lineup, are all manufactured in-house under strict quality control and can be delivered to you in a short period. Additionally, by utilizing our assay kits, contract profiling services, and cell-based assay services that use these in-house manufactured protein products, you can significantly shorten your exploration time. Through partnerships with overseas companies, we also offer a wide range of services, including cell-based assays using Ba/F3 and HEK293, as well as crystallization structure analysis. Please feel free to contact us.