Ultrasound Gene Introduction & FUS System Sonopore KTAC-4000
The Sonopole 4000 is a wide-area high-frequency transmitter and amplifier with excellent operability, designed for sonoporation, a non-invasive method for introducing genes and drugs into cells and tissues. The output frequency, output wattage, pulse duty ratio, burst rate (repetition cycle), and sweep function (automatic frequency variation) are continuously variable, allowing for the setting of various combinations of experimental conditions. Automatic measurement of the actual output wattage is possible, and it is displayed in real-time, enabling confirmation of the output wattage during experiments. The probe is a flexible type that can be replaced, and the ultrasonic transducer at the tip is compact, allowing irradiation of areas that were previously difficult to target, thus expanding experimental possibilities. The combination with microbubbles can enhance gene delivery efficiency. It can be used for both In Vivo and In Vitro experiments with a single unit. Please contact us for custom probes.
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basic information
Frequency…500k～5,000kHz * Adjusts to the optimal frequency of the ultrasonic probe. * Equipped with automatic frequency variation function (sweep function). Ultrasonic intensity…Output: maximum 15W, Setting: 0～60V *Varies by probe. Duty Cycle…0～100% Burst Rate (repetition cycle)…0.5～100.0Hz Time…Automatic timer (0～99s) or manual. Waveform…Sine wave or square wave. Automatic frequency variation (sweep function)…No setting + 4 types of sweep modes (right-tilt sweep, left-tilt sweep, peak-tilt sweep, valley-tilt sweep). Frequency variation range…±0.1～99.9% (based on the set frequency). Sweep interval…0.2ms～100.0msec. Power supply, dimensions, weight…100～240V, 320W × 350D × 149Hmm, 8kg.
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Applications/Examples of results
● DNA/RNA/drug/virus introduction ● HIFU research ● Combined effects with photosensitizers ● Cell proliferation
Company information
Neppajine takes pride in contributing to the peace and progress of humanity through biotechnology as a specialized company in life science research equipment, including electroporation (gene introduction using electric pulses) and sonoporation (gene introduction using ultrasound). We believe it is our mission to provide excellent products and information not only within Japan but also to universities, research institutes, hospitals, and private companies around the world. In practice, we have numerous products in use, including gene introduction devices, cell fusion devices, and ultrasound gene introduction devices. We continuously absorb cutting-edge knowledge and technology in biotechnology, engage in close sales activities with our users, provide the latest products, technologies, and information, and respond with a rapid maintenance system. Towards the development of humanity and a bright, happy future, Neppajine will continue to move forward strongly alongside biotechnology.