Cell Stretching and Compression Stimulus Device
● Cells in the body are constantly subjected to various (periodic and intermittent) mechanical stimuli. In contrast, such stimuli are absent in conventional static culture (In Vitro). As a result, cultured cells in static conditions differ from cells in the body (In Vivo) in many ways. The cultured cell stretching device is a system that allows cells to be cultured in conditions closer to the in vivo environment by applying periodic uniaxial (or biaxial*) stretching and compression stimuli to the cultured cells. ● It can be used for research on various adhesive cells such as endothelial, smooth muscle, epithelial, cardiac, adipose, skeletal muscle, fibroblast, osteoblast, and cartilage, as well as for studies related to regenerative medicine. ● It can set up 64 different stimulation patterns with 8 combinations of stretching and compression rates and 8 combinations of stimulation frequencies. ● The system has excellent expandability, and when used for large-scale culture, it can be applied to biochemical experiments at the gene and protein levels. ● The ultra-thin silicone membrane chamber allows for various fluorescence imaging observations.
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basic information
Model: NST-140, NST-150, NST-190-XY, NST-400
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Applications/Examples of results
● Physical stimulation experiments on cardiomyocytes, vascular endothelial cells, chondrocytes, fibroblasts, etc. ● Cell morphology (fluorescent immunological experiments on the cytoskeleton and cell adhesion sites) ● Mechanosensitive mechanisms (signal transduction, protein expression, gene expression, ion channels) ● Regenerative medicine (chondrocytes, osteocytes, vascular progenitor cells, stem cells)
Company information
Neppajine takes pride in contributing to the peace and progress of humanity through biotechnology as a specialized company in life science research equipment, including electroporation (gene introduction using electric pulses) and sonoporation (gene introduction using ultrasound). We believe it is our mission to provide excellent products and information not only within Japan but also to universities, research institutes, hospitals, and private companies around the world. In practice, we have numerous products in use, including gene introduction devices, cell fusion devices, and ultrasound gene introduction devices. We continuously absorb cutting-edge knowledge and technology in biotechnology, engage in close sales activities with our users, provide the latest products, technologies, and information, and respond with a rapid maintenance system. Towards the development of humanity and a bright, happy future, Neppajine will continue to move forward strongly alongside biotechnology.