Pharmacological evaluation of a diet-induced NASH hamster model with human-like cholesterol metabolism characteristics.
Unlike mice and rats, hamsters exhibit human-like cholesterol and bile acid metabolism characteristics. Therefore, pharmacological tests with the FXR agonist obeticholic acid show human-like weight and liver inflammation suppression, as well as side effects such as increased LDL cholesterol and decreased HDL cholesterol. (In mice and rats, this cholesterol side effect is reversed, with decreased LDL cholesterol and increased HDL cholesterol.) Physiogenex has adopted a cafeteria diet approach to induce this hamster model for overfeeding and NASH (non-alcoholic steatohepatitis) by providing a high-fat diet and high fructose water. This induces obesity, insulin resistance, hypercholesterolemia, and elevated ALT levels. This test system allows for efficacy evaluation studies targeting obeticholic acid and Elafibranor (GFT505), based on human-like cholesterol and bile acid metabolism characteristics. For more details, please contact us. *Inquiries can also be made through our website. We will respond promptly. (Search for "Clea Japan" at http://www.clea-japan.com/)
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basic information
Example of Implementation: 5 Groups (n=10) Configuration Group 1 is the control, Groups 2-4 receive the test compound (dosage: 3 doses), and Group 5 receives a commercial drug. Protocol Overview: (For details, please contact us) - 5 days of acclimatization for 6-week-old male hamsters - Feeding and watering using a cafeteria diet starting at 7 weeks of age - Randomization into groups based on HOMA-IR, total cholesterol, LDL cholesterol, and ALT 20 weeks after feeding and watering (at 26 weeks of age). Drug administration period (5 weeks) - Parameters that can be measured: Plasma lipids, ALT/AST, HOMA-IR, liver lipids, gene expression, pathological analysis (H&E, ORO, Sirius Red staining), NAS scoring *Inquiries can also be made from our website. We will respond promptly. (Search for "Clea Japan" http://www.clea-japan.com/)
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Delivery Time
※Approximately 6 months from the exam period to the final report.
Applications/Examples of results
Main Academic Presentations Presentation The Liver Meeting 2016 (November 2016) Title Farnesoid X Receptor Agonist Obeticholic Acid Raises LDL-cholesterol and Reduces HDL-cholesterol in the Diet-induced NASH (DIN) Hamster, a Novel Preclinical Model for Evaluating Efficacy and Side Effects of Drugs Targeting Non-Alcoholic Liver Diseases. *Inquiries can also be made through our website. We will respond promptly. (Search for "Clea Japan" http://www.clea-japan.com/)
Company information
Nihon Kurea Co., Ltd. is a company primarily engaged in the production and sale of laboratory animals, the manufacture and sale of laboratory animal feed, and the manufacture and sale of laboratory animal housing equipment, tools, facilities, and devices. In response to research using laboratory animals, we have been working on the development and improvement of various types of laboratory animal feed. Currently, there are 15 different brands available. These feeds are supplied under strict management from the procurement of raw materials to formulation, manufacturing, product inspection, storage, and transportation, in accordance with the regulations of the "Nihon Kurea Co., Ltd. Business Standards for Management Criteria Related to Laboratory Animal Feed," with the aim of maintaining consistently stable quality and improving reliability.
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