Catalog Presentation: HDO Technology, which is expected to improve enzyme resistance in the bloodstream and reduce toxicity.
Our company handles "Hetero Double-Stranded Nucleic Acid (HDO)," which can selectively deliver active strands to disease sites by binding ligands to carrier strands, thereby expecting high therapeutic efficacy. HDO has a double-stranded structure, making it inherently stable. It avoids chemical modifications to the active strand, which can reduce toxicity. 【Features】 ■ Selectively delivers active strands to disease sites, achieving high therapeutic efficacy ■ Avoids chemical modifications and reduces toxicity ■ Provides a structurally stable material, improving enzyme resistance in the bloodstream ■ Low likelihood of unexpected therapeutic effects ■ Allows for free selection of the position and number of ligands binding to the carrier strand ■ The HDO technology is licensed to Takeda Pharmaceutical Company Limited, Ionis Pharmaceuticals (USA), Nippon Shokubai Co., Ltd., and Nippon Gene Material Co., Ltd. ■ The HDO technology is covered by multiple registered patents, ensuring safe use. ■ Collaborative research using HDO technology for drug discovery can also be conducted with our company. *For more details, please download the PDF or contact us.
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basic information
**Mechanism of Action of HDO** ■Step 1 → HDO taken up into the cell is cleaved by RNase H (enzyme), resulting in the carrier strand (RNA strand) being cut. ■Step 2 → The remaining active strand (DNA strand) after cleavage binds to the target mRNA. ■Step 3 → The active strand (DNA strand) binding to mRNA forms a DNA/RNA structure again, leading to the cleavage of the target mRNA by RNase H. ■Step 4 → The cleavage of mRNA suppresses mRNA expression, resulting in the manifestation of the drug's efficacy. *RNase H has the property of cleaving RNA in a double strand composed of DNA/RNA.* *For more details, please download the PDF or feel free to contact us.*
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Our company holds the following two seeds: - NASH therapeutic agent that regulates the expression of the IHH gene (early seed) - Tumor cell malignancy suppressor and melanoma therapeutic agent that regulates the expression of the ZIC5 gene (early seed)
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Company information
Renac Therapeutics Co., Ltd. aims to create new nucleic acid drugs through a platform-based business model. Instead of a business model that derives profits by licensing out drugs developed through in-house research to pharmaceutical companies (the so-called pipeline model), we are developing a business model that collaborates with pharmaceutical companies from the drug discovery research stage and jointly develops drugs with them.