Contract for the production of genetically modified mice: Creation of Rosa26 knock-in mice.
We will provide the production of knock-in mice using various vector backbones!
We are engaged in the production of "Rosa26 Knock-in Mice." The Gt (ROSA) 26Sor gene is a genetic locus discovered by Phillip Soriano and others using the gene trap method with the ROSA (reverse orientation splice acceptor) vector. The reason many knock-in mice have been created for this genetic locus is that "transcription from the ROSA26 promoter, while not uniform, is ubiquitous." We provide the production of knock-in mice at the Gt (ROSA) 26 Sor locus using various vector backbones. 【Features】 ■ Has ubiquitous promoter activity and is less susceptible to epigenomic effects ■ Stable expression of the gene is possible even when introducing foreign promoters ■ The phenotype of Rosa26 gene disruption does not appear even in homozygous mice ■ High homologous recombination efficiency in ES cells ■ An inducible expression system using Cre/loxP can also be constructed *For more details, please refer to the PDF materials or feel free to contact us.
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【Work Process】 ■ Construction of recombinant vectors ■ Establishment of recombinant ES cell lines ■ Production of chimeric mice ■ Production of heterozygous mice *For more details, please refer to the PDF materials or feel free to contact us.
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For more details, please refer to the PDF document or feel free to contact us.
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Our company is engaged in the production of gene knockout mice, providing genetic information to research institutions such as universities and pharmaceutical companies, selling reagents, and conducting non-clinical and clinical trial contracts, as well as pathological diagnosis. Through the development of biological resources from individual organisms to genomes, we provide genetic information for foundational research and in the fields of medicine and healthcare. Please leave the production and sale of knockout mice, gene knockout mice, and antibodies to us.