Immune modulation, antioxidant effect, promotion of superoxide dismutase (reactive oxygen species decomposition enzyme) production, anti-aging (elasticity, wrinkles, smoothness)
Carboxymethyl glucan (CMG) is a derivative of β-glucan isolated from yeast cell walls and is a natural yeast polysaccharide. While β-glucan is insoluble, this product has been made water-soluble while maintaining its biological activity through carboxymethylation. CMG significantly increases superoxide dismutase (SOD) activity, which shows important immune-regulating and antioxidant effects. These mechanisms help protect the skin from UV stress. = In Vitro = - Maintenance of glutathione pool (UV) - Promotion of SOD (reactive oxygen species-decomposing enzyme) production (UV): 40% increase - Inhibition of cellular phospholipid oxidation (UV): 80% inhibition - Inhibition of cellular protein oxidation (UV, vs TiO2): 22% inhibition - Inhibition of inflammatory cytokine (IL-6) (UV): 20% inhibition - Inhibition of inflammatory cytokine (IL-1beta) (UV): 40% inhibition - Promotion of anti-inflammatory cytokine (IL-10) production (UV): 60% increase = In Vivo = - Increase in collagen fibers and dermal papilla cells - Improvement in skin smoothness - Reduction in pore size - Improvement in skin elasticity - Improvement in crow's feet wrinkles
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Carboxymethyl glucan (CMG) is a derivative of β-glucan isolated from yeast cell walls and is a natural yeast polysaccharide. While β-glucan is insoluble, this product has been made water-soluble while maintaining its biological activity through carboxymethylation. CMG significantly increases the activity of superoxide dismutase (SOD), which exhibits important immune-regulating and antioxidant effects. These mechanisms help protect the skin from UV stress. =In Vitro= - Maintenance of glutathione pool (UV) - Promotion of SOD (reactive oxygen species decomposing enzyme) production (UV): 40% increase - Inhibition of cellular phospholipid oxidation (UV): 80% inhibition - Inhibition of cellular protein oxidation (UV, vs TiO2): 22% inhibition - Inhibition of inflammatory cytokine (IL-6) (UV): 20% inhibition - Inhibition of inflammatory cytokine (IL-1beta) (UV): 40% inhibition - Promotion of anti-inflammatory cytokine (IL-10) production (UV): 60% increase =In Vivo= - Increase in collagen fibers and dermal papilla cells - Improvement in skin smoothness - Reduction in pore size - Improvement in skin elasticity - Improvement in crow's feet wrinkles
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Day creams 0.01 – 0.1 % Night creams 0.01 – 0.1 % Eye creams 0.01 – 0.1 % Serums 0.01 – 0.1 % Tonic 0.01 – 0.05 % Body lotions 0.01 – 0.05 % After sun lotion 0.01 – 0.1 % Sunscreen lotion 0.01 – 0.1 % After shave lotions/balms 0.01 – 0.05 %
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Starting as an import trading company in 1927, we have been developing our business with many overseas suppliers and domestic customers over the years. Through our services of connecting the two together, Higuchi has become the well trusted "Japan distribution channel" for suppliers, and the "dependable vendor" who provides a stable supply of the latest high-valued overseas products to customers. Today, we conduct not only importing but also exporting businesses, trilateral trades, and overseas business investments as well. We have also expanded to local subsidiaries in the United States and China, to which we are able to effectively network overseas. Higuchi believes in the criticalness of providing a stable supply to customers, and we also place the highest priority on the coexistence with suppliers, to whom we can mutually develop together in a long-term perspective. Your support and consideration to our corporate philosophy would be much appreciated.