"Streamlining lab-scale concentration, desalting, and buffer exchange processes" *Demo units available for loan!*
Tangential flow filtration (TFF) is a filtration method that applies a constant pressure to the membrane side by flowing liquid samples parallel to the membrane surface, allowing solutes and small molecules to pass through the membrane. Compared to conventional direct flow filtration, TFF is less prone to filter clogging because it is continuously perfused parallel to the membrane surface, enabling efficient and large-capacity ultrafiltration. The Minimate EVO TFF system is suitable for large-scale protein and nucleic acid purification and is equipped with Omega membranes that have a wide range of molecular weight cut-offs (MWCO) from 1K to 1000K. It is also suitable for applications that require the purification of exosomes, which are extracellular nano-vesicles, from large volumes of cell culture media. It has been reported that TFF methods have a higher recovery rate of exosomes from cell culture media compared to ultracentrifugation [1], and there are also proven results with Minimate [2]. If you are considering large-volume sample ultrafiltration, please feel free to contact us. [1] Busatto S., et al., Cells, 7, 273-283 [2] Sung SE., et al., Int J Mol Sci, 22, 2889-2900
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basic information
The Minimate EVO system is a large-capacity sample (~1 L) ultrafiltration system by TFF. Demonstrations and rentals are available! Try it with actual samples! 【Features】 - Fast and efficient: Concentration and desalting operations can be performed simultaneously. - High recovery rate: Achieves a high recovery rate with low protein adsorption. - Economical: Depending on the application, membranes can be cleaned and reused. - Compact: Compact size takes up little space. 【Package Contents】 • MasterFlex® L/S variable speed pump, with L/S Easy-Load pump head • VWR® magnetic stirrer • 500 mL sample reservoir with lid (includes fittings and O-rings for the lid) • Fittings and O-rings • Drip tray • Pressure gauge • Adjustable drip tray legs • Power cord for the pump (100V-250V AC: not a current conversion plug) • Power cord for the magnetic stirrer (power 100V-240V AC, input voltage 12V DC) • Fittings/parts bag
Price information
For inquiries regarding delivery dates, prices, and demo requests, please use the inquiry form or the contact button.
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Applications/Examples of results
● Concentration and desalting of proteins, peptides, and nucleic acids (DNA, RNA, oligonucleotides) ● Purification and concentration of exosomes ● Recovery of antibodies and recombinant proteins from culture supernatants after cell (microbial) separation ● Separation processes for metal-sensitive enzymes and molecules ● Concentration of viruses and gene therapy vectors ● Sample pretreatment before column chromatography ● Sample concentration after gel filtration ● Removal of pyrogens from water, buffer solutions, and culture media solutions
Detailed information
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Tangential Flow Filtration (TFF) MiniMate EVO System
Company information
Cytiva and Pall Life Sciences have merged their businesses and will officially launch under the "Cytiva" brand on May 1, 2023. Under our mission of "Advancing therapies, faster," we will integrate both organizations and focus even more on supporting the development and manufacturing of better therapies for patients as a stronger global provider of technologies and services. The new Cytiva will offer a broader and deeper expertise and a rich lineup of products and services to better support various customers involved in research and the manufacturing and development of biopharmaceuticals, enabling them to deliver therapies to patients more quickly, from discovery to delivery. With a rich history spanning several hundred years, Pall Life Sciences and Cytiva, as part of the Danaher Group, will continue to unite to provide better services to our customers.
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