Artificial membranes that can be used for drug membrane permeability rate testing. In vitro evaluation of membrane permeability in non-clinical stage drugs such as oral and gastrointestinal membranes is possible.
It is a multilayer structure that sandwiches phospholipids between cellulose films. It can be stored long-term at room temperature and does not require any pretreatment, allowing for immediate use when needed. Being a homogeneous artificial membrane, it provides high measurement reproducibility. Stable testing is possible over a wide pH range. It can also be used with samples containing solvents such as ethanol and DMSO, surfactants, and biomimetic solvents.
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basic information
Test temperature: e.g. 25℃, 37℃ (tests can be conducted at other temperatures as well) pH range: 1-10 pH Reagent concentration: e.g. 5mM Test duration: up to 24 hours Wells: 96 Material: Polystyrene (plate part) Storage conditions: Can be stored at room temperature (must be protected from direct sunlight and ultraviolet light) Expiration date: 1 year
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Delivery Time
P4
Applications/Examples of results
As an alternative to biological membranes in permeability testing. - Drug pharmacokinetics in drug discovery research - Evaluation of intestinal absorption of drugs during oral administration - A preliminary screening tool for CaCo-2 permeability tests - An alternative method to the PAMPA (Parallel Artificial Membrane Permeability Assay) The concentration of components that have permeated the membrane is analyzed using HPLC or LC-MS.
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Company information
Eihon Seiki consists of two business areas: "Environment and New Energy" and "Physical Property Analysis." The Physical Property and Analysis Division imports and sells unique products from around the world. In addition to ISO 9001 and ISO 14001, we have obtained ISO 17025 accreditation for "Calibration of Direct Solar Radiation Meters and All-Sky Solar Radiation Meters" and "Viscosity Measurement and Viscosity Meter Calibration."
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