Amino acids with side chains controlled by SpiroKit3 conformation.

Composed of controlled stereochemistry amino acids! Special amino acids with β-amino acids and spiro rings as the backbone are also utilized.

Stereochemically restricted amino acids have become one of the fundamental building blocks in modern drug discovery chemistry, allowing for the expression of important structural features in drug design by controlling the conformation of side chains in these amino acids. Specifically, by combining amines and carboxylic acids functionalized at chiral centers with side chains that have restricted stereoconformation, it is possible to achieve unique three-dimensional structures with functionality. In this way, restricted amino acids provide diverse information for investigating structure-activity relationships and are essential components in peptide mimetics. Additionally, due to their unique three-dimensional structures, these amino acids serve as special motifs to enhance pharmacological activity, selectivity, and ADME, and are expected to improve membrane permeability, oral bioavailability, and metabolic stability. 【SpiroKit3 Features】 ■ Composed of stereochemically controlled amino acids ■ In addition to α,α-disubstituted amino acids, special amino acids with β-amino acids and spiro rings as their framework are also included. *For more details, please refer to the PDF document or feel free to contact us.

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