Scalable single-use automated centrifugation system
The kSep system is a fully automated single-use centrifugation system that continuously concentrates, washes, and recovers supernatant or solids (cell particles). It is ideal for cell separation from fed-batch culture, high-density culture, and concentrated culture, maintaining a high cell survival rate with minimized shear stress, addressing the challenges of traditional centrifugation and filtration-based technologies.
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basic information
The kSep system is a single-use system in a completely closed configuration, featuring a bowl-shaped centrifuge that does not stop rotating during discharge. It reduces contamination in downstream processes and guarantees high-quality products. With a recovery rate exceeding 97% and low shear forces, it collects pure cells. The principle of the kSep system involves maintaining a balance between centrifugal force and fluid dynamics, continuously flowing media or buffers while retaining and concentrating particles such as cells and microcarriers in a conical single-use chamber. The system can be operated under aseptic conditions, and all consumables are gamma-sterilized.
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Applications/Examples of results
- Recombinant therapy - Cell therapy (MSC, CAR-T cell, iPS, etc.) - Vaccine production - Blood processing
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Company information
Sartorius Stedim, established in 2007 through the merger of the German company Sartorius, founded in 1870, and the French company Stedim, is a pioneer in "Single-Use Technology (SUT)." As a company capable of providing comprehensive technical support to the pharmaceutical and biotechnology industries, its cutting-edge technology is highly regarded worldwide in the fields of scientific instruments and biotechnology.