We contribute to the research and development of pharmaceuticals, food, and chemicals worldwide with the chimeric mouse 'PXB mouse,' in which the liver organ is completely replaced with a human liver.
The "PXB Mouse" is an experimental animal that has a human liver, making it closer to humans. As a result, it is possible to predict the efficacy and safety in humans with a higher probability than traditional animal testing in non-clinical trials for drug development. This can improve the success rate of new drug development and, as a result, reduce the time and cost involved in development. 【Features of the "PXB Mouse"】 ■ It has a high replacement rate of human liver. ■ It forms normal human liver tissue. ■ It expresses human-type genes, enzymes, and transporters in the liver. ■ It can sustain infection with hepatitis viruses (HBV, HCV) that only infect humans. *For more details, please refer to the PDF document or feel free to contact us.
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basic information
Reasons for Choosing "PXB Mice" ■ Guarantees a high human liver cell replacement rate of over 70% ■ Unmatched stable production capability of PXB mice in the world ■ Supply of high-quality chimeric mice backed by high production capacity ■ Long-term maintenance of a stable and high degree of humanization *For more details, please refer to the PDF document or feel free to contact us.
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Applications/Examples of results
【Applications】 ■ Pharmacokinetic evaluation (human metabolite prediction, PK prediction, drug interaction) ■ Safety evaluation (human hepatotoxicity, biomarker exploration) ■ Hepatitis virus (HBV/HCV) efficacy and pharmacological evaluation ■ New modality drug discovery evaluation (nucleic acid medicines, gene therapy, antibody drugs) ■ Efficacy and pharmacological evaluation of new human disease models (NASH, congenital metabolic disorders) *For more details, please refer to the PDF document or feel free to contact us.
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Company information
Our company offers contract testing services for drug development using PXB mice, which are high-quality human liver cell chimeric mice, as well as PXB mouse-related products. We have developed a technology that focuses on the function and proliferation ability of human liver cells, allowing them to proliferate in large quantities within experimental animals while maintaining their functionality. We are expanding a new business that provides the functions of human liver cells in a way that is easy to utilize for various applications.