The amounts of leaked protein A and host-derived DNA have been reduced to below the detection limit!
In the downstream (purification process) of monoclonal antibody (mAb) manufacturing, it is common to use chromatography resin for the Protein A column capture step and the polishing step, which is called impurity removal. This document introduces a method that connects two columns used in the polishing step and employs them in flow-through mode. By using this method, we were able to efficiently remove impurities without the cumbersome operations of adjusting pH and electrical conductivity between the polishing process columns. [Contents] ■ Introduction ■ Experimental Methods ■ Analysis ■ Results ■ Conclusion ■ Acknowledgments *For more details, please refer to the PDF document or feel free to contact us.
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Our group was founded in 1906 as Sogi Electric Co., Ltd., and since then, we have been a pioneer in Japan's chemical industry, contributing to the development of society by expanding renewable energy generated by hydropower into the field of electrochemistry and developing domestic nitrogen fertilizers. Our unchanging mission is to engage in manufacturing that harmonizes with the global environment, to solve our customers' challenges in order to realize a rich life, and to cultivate outstanding human resources who can thrive globally, continuously serving society.
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