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  6. Cosmetic ingredient Circadian rhythm regulating ingredient CIRCALYS

Cosmetic ingredient Circadian rhythm regulating ingredient CIRCALYS

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last updated:Jan 19, 2026

HIGUCHI INC.
HIGUCHI INC.
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Circadian rhythm adjustment, skin stress relief, anti-fatigue, skin activation, anti-aging, improvement of dark circles, reduction of tear bags, wrinkle improvement, enhancement of radiance.

In the midst of rapid social development, our bodies are being attacked by various environmental and stress factors (night shifts, overtime, lack of sleep, etc.). This stress disrupts the body's natural rhythms (circadian rhythms). Skin homeostasis is also maintained by circadian rhythms, and disturbances in these rhythms can lead to a decline in skin health and beauty (symptoms of fatigue appearing on the face: dark circles, bags under the eyes, fine lines, dull complexion, etc.). A decrease in perceived beauty may also lead to a reduction in mental health and feelings of happiness. SARCALIS helps regulate circadian rhythms and cares for skin, mind, and fatigue. In Vitro - Restores the expression levels of clock genes CLOCK, CRY1, and PER to youthful levels. - SIRT1 (anti-aging gene): +56% - KLOTHO (anti-aging gene): +33% - HIF-1α (maintenance of skin homeostasis): +89% - 8-OHdG (marker of DNA damage): -51% - Oxytocin levels: +31% (feelings of happiness) - Endocannabinoid levels: +68% (stress reduction) - Endorphin levels: +55% (good mood) and more. In Vivo - Size of bags under the eyes: -28% - Darkness of dark circles: -13% - Wrinkles under the eyes: -21% - Skin stress relief and more.

    Cosmetic materials and raw materialsOther pharmaceutical intermediates and cosmetic ingredientsOther medical supplies and cosmetic manufacturing materials
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Cosmetic ingredient Circadian rhythm regulating ingredient CIRCALYS

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サーカリス表紙_page-0001.jpg
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basic information

Green Tech Co., Ltd. is a company established in 1992. The company has been importing and selling various types of plant extracts in Japan for about 20 years, and we have heard that Japanese customers perceive Green Tech as a manufacturer with a wide range of plant extracts. In fact, the company handles over 5,000 types of plant extracts. In addition to traditional plant extracts, we also produce and sell products that focus on the biodiversity of South America, particularly Brazil and the Amazon, including plant extracts and oils, as well as products developed based on microbiome research that demonstrate effectiveness in maintaining microbial community homeostasis. We also manufacture and sell products derived from algae and microalgae, including components and extracted extracts. In recent years, we have been focusing on research and development, not only enhancing the evaluation data for our products in In-Vivo and In-Vitro studies but also conducting research and development in response to new trends such as skin microbiomes. Additionally, we are committed to the development and manufacturing of products that have demonstrated effectiveness by increasing the concentration of active ingredients using our proprietary freeze technology (preservation, grinding, extraction) and fermentation technology. These manufacturing technologies are not only applicable to the development of our own products but also support the development of customized products.

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Recommended usage: 1-5% Cold process addition is recommended. - Night care products - Anti-fatigue products - Urban protection products - Skin activation products - Relaxation care products and so on.

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Cosmetic ingredient Circadian Rhythm Regulating Ingredient CIRCALYS

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Cosmetic and drug discovery monitor cells, circadian rhythm monitor cells.

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Company information

HIGUCHI

HIGUCHI INC.

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Starting as an import trading company in 1927, we have been developing our business with many overseas suppliers and domestic customers over the years. Through our services of connecting the two together, Higuchi has become the well trusted "Japan distribution channel" for suppliers, and the "dependable vendor" who provides a stable supply of the latest high-valued overseas products to customers. Today, we conduct not only importing but also exporting businesses, trilateral trades, and overseas business investments as well. We have also expanded to local subsidiaries in the United States and China, to which we are able to effectively network overseas. Higuchi believes in the criticalness of providing a stable supply to customers, and we also place the highest priority on the coexistence with suppliers, to whom we can mutually develop together in a long-term perspective. Your support and consideration to our corporate philosophy would be much appreciated.

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