Human-type P-gp mouse "TC-huMDR1"

In vivo evaluation model mice for predicting drug brain permeability and intestinal absorption.

The TC-huMDR1TM mouse is a trans-chromosomic (Tc: chromosomal insertion) mouse (B6 strain) that introduces the human MDR1 gene into a mouse that has knocked out the intrinsic mdr1a/1b genes (mMDR1-KOTM) using an "artificial chromosome vector," making it the world's first 'human-type P-gp model mouse' that expresses functional P-glycoprotein (P-gp). Features and Benefits: * Functional human P-gp protein is expressed. * The AUC of TC-huMDR1TM mice and mMDR1-KOTM mice can be used to evaluate human brain permeability and P-gp-mediated drug-drug interactions. * Using TC-huMDR1TM mice and physiological pharmacokinetic (PBPK) modeling, quantitative predictions of human nonlinear absorption mediated by P-gp can be made. * This allows for the selection of compounds with ideal pharmacokinetic profiles in drug discovery, facilitating more appropriate management of P-gp-mediated drug-drug interactions in clinical settings. *For more details, please refer to the PDF materials or feel free to contact us.*

Other experimental consumablesOther experimental equipment and suppliesOther animal and plant experimental equipment and instruments