This is a device that facilitates the analysis of the toxicity and efficacy of drugs on the contractile force of cardiac muscle cells.
This is a device that measures the contraction force of string-like cardiac tissue composed of cardiomyocytes in real-time. It allows for easy analysis of the toxicity and efficacy of drugs on the contraction force of cardiomyocytes. The production of string-like cardiac tissue is easy in a dedicated bioreactor. Research on both acute and chronic phases is also possible.
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basic information
This device consists of the following four components: - CTScreen main system - Computer with measurement/analysis software - Perfusion and temperature control system - Electrical stimulation system
Price range
P7
Delivery Time
Applications/Examples of results
Analysis of the toxicity and efficacy of drugs on the contractile force of cardiac muscle cells Achievement 1 An analysis of the effects of the antimalarial drugs Hydroxychloroquine (HCQ) and azithromycin (AZM) on cardiac muscle cells revealed that AZM exhibited a dose-dependent negative inotropic effect, which was exacerbated by HCQ. J Mol Cell Cardiol. 2021 Apr;153:106-110. doi: 10.1016/j.yjmcc.2020.12.014. Achievement 2 Using human pluripotent stem cell-derived ventricular cardiomyocytes with a Frataxin (FXN) gene knockout as a model for Friedreich's ataxia, we created string-like cardiac tissue and analyzed its contractile force, finding a 70-80% reduction compared to healthy controls. Additionally, it was confirmed that recovery of FXN protein levels through lentiviral introduction restored the contractile force deficiency in FXN-deficient hvCTS. Stem Cell Res Ther. 2019 Jul 8;10(1):203. doi: 10.1186/s13287-019-1305-y.
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Company information
After developing a high-speed imaging device necessary for neuroscience research, Brain Vision was established in May 1998 as an official venture of RIKEN with the aim of commercializing various ideas that emerged during neuroscience research. To date, over 100 high-speed imaging devices have contributed to advanced research activities at major neuroscience and cardiac research institutions around the world. In recent years, it has also been highly regarded in the field of optoelectronics and has already contributed to research and development at related research institutions and liquid crystal manufacturers. Further contributions in various industrial fields are expected in the future. Brain Vision aims to provide innovative technologies born from neuroscience research to the market and contribute to the advancement of science and industry.