Nucleic acid synthesis-related products

basic information

■Structure of Nucleic Acids Nucleic acids refer to deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). They have a repetitive structure of nucleotides. The building blocks, nucleotides, consist of a nucleic acid base, a five-carbon sugar (ribose), and phosphate. ■Nucleic Acid Medicines Nucleic acid medicines are gaining attention as a new drug discovery modality. They are drugs based on natural or chemically modified nucleotides, which act directly on the body without mediating gene expression and are characterized by being produced through chemical synthesis. ■Synthesis of Nucleic Acids (Oligonucleotides) Current nucleic acid (oligonucleotide) synthesis primarily uses the solid-phase synthesis method (phosphoramidite method) developed in the 1980s. Nucleotides are added on solid-phase supports such as polymer beads, repeating the synthesis cycle until the desired chain length is achieved, with the following steps 1 to 4 constituting one cycle. 【Synthesis Cycle】 1. Deprotection: Removal of protective groups from the reaction site 2. Coupling: Reaction of nucleic acid monomers 3. Capping: Protection of unreacted materials 4. Stabilization: Oxidation or sulfuration after coupling ↓ 5. Post-processing 6. Purification

Price range

Delivery Time

Applications/Examples of results

For more details, please refer to the catalog below or feel free to contact us.