Automated Analysis Device for Cell Culture Environment 'BioProfile FLEX2'

Dialogue Webinar "CELL & GENE THERAPY" Date and Time: December 1, 2023 (Thursday) 13:00～ *Please check "Nova Biomedical" as a result of discovering the site when applying for the course. Organizer: Dialogue Inc. Webinar Content "Gene Therapy" December 1, 2023 (Friday) *Featuring a presentation on the latest technology from Nova Biomedical! Invited Speaker Dr. Toru Uchiyama (National Center for Child Health and Development) Chairpersons Mr. Tomoyuki Ikawa (Chugai Pharmaceutical Co., Ltd.), Mr. Hiroyuki Sonoda (JCR Pharmaceuticals Co., Ltd.) Mr. Wataru Takahashi (Daiichi Sankyo Co., Ltd.), Mr. Yoshitaka Nakamura (Nippon Shinyaku Co., Ltd.) Startup/Bioventure Presentations Mr. Akimitsu Hirai (C4U Inc.), Mr. Shigeki Yagyu (A-SEEDS Inc.), Mr. Tetsuya Saito (Celgentec Inc.) Ms. Tomoko Inoue (JOCAVIO Inc.) Technical Presentations Mr. Soji Murayama (Beckman Coulter Inc.), Mr. Hironobu Yamanaka (Nova Biomedical Inc.) Mr. Yukinori Hatta (Bio-Rad Laboratories Inc.) Please check the application page for more details.

This webinar is available for on-demand viewing at any time. [Fundamentals and Research Applications of Culture Media] (Approximately 45 minutes) In the first part of this webinar, we will explain the history of culture media in cell culture, examples of basic and applied uses, and how the selection of culture media and its components contributes to cost, safety assurance, and quality control. We will also discuss the approach to conducting culture media analysis. In the latter part, we will demonstrate the usefulness of utilizing cell culture media analysis for quality control in experiments and research aimed at enhancing the reproducibility of cell culture experiments and studies, using specific case examples. Speaker: Dr. Masanobu Horie, Ph.D. (Engineering) Assistant Professor, Kyoto University, Environmental Safety and Health Organization

This webinar is available for on-demand viewing at any time. 【The Importance of Main Process Measurement for Cell Quality Control】 (Approximately 50 minutes) This webinar consists of two major parts. First, it covers the latest trends in quality control for cell manufacturing, including the Quality by Design (QbD) quality management concept, its international standardization activities, and Japan's leadership in this area. Secondly, the speaker will present research findings on in-process monitoring of cell manufacturing using techniques such as metabolite monitoring and image analysis. This webinar provides highly insightful information for anyone involved in research and development, manufacturing, or quality control of cell production. Speaker: Dr. Ryuji Kato (Ph.D. in Engineering)

**Introduction of a New Automatic Sampling System for High-Density Cell Culture Processes** (Approx. 55 minutes) This presentation is recommended for researchers and engineers, primarily from companies, who are engaged in the development, automation, and scale-up of high-density cell culture processes in bioreactors. The speaker, an expert with experience in high-density cell culture process development at a pharmaceutical company, will present findings from a collaborative project conducted with Merck and other universities at the University of Applied Sciences and Arts Northwestern Switzerland. **Speaker:** Patrick Roman University of Applied Sciences and Arts Northwestern Switzerland **Overview** A comprehensive and detailed evaluation of the "automatic sampling system," which connects FLEX2 to a perfusion bioreactor, including an auto-sampler and sample collector. The presentation will cover approximately 35 minutes, featuring "an overall schematic diagram of the installation situation, including sterile connections to the reactor, along with abundant photographs" and "evaluation of the auto-sampler (comparison of manual and automatic data discrepancies, system robustness testing, sterility of the system, etc.)." The QA session will highlight "technical troubleshooting overcome before system operation" and "the reality of labor-saving that goes beyond just eliminating the need for weekend operators."