For asymmetric fluorination of the active methylene group in β-keto ester compounds!
At Kanto Chemical, the chiral spirodiamine ligands SPYMOX and SQUMOX, developed by Professor Kazutaka Shibatomi and others at Toyohashi University of Technology, efficiently facilitate asymmetric halogenation of various β-keto ester compounds through complex formation with copper. They also demonstrate a broader substrate generality and asymmetric induction capability compared to conventional methods. These ligands can coordinate with various transition metals and can be utilized as optically active diamine ligands in various catalytic reactions. 【Features】 - Achieves broad substrate generality and advanced stereocontrol for activated methine compounds. - Uses ubiquitous copper instead of rare metals. - Enables highly enantioselective asymmetric fluorination and asymmetric chlorination of active methine groups. - Allows for sequential asymmetric chlorination and fluorination in one pot by using different halogenating agents in succession on activated methine groups. For more details, please download the catalog or feel free to contact us.
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basic information
Halogen atoms are widely used as important leaving groups in organic synthesis. Additionally, in the fields of pharmaceuticals and functional materials, there are numerous reports of performance improvements through the introduction of fluorine atoms, establishing them as one of the important methods in these areas.
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For more details, please refer to the catalog below or feel free to contact us.
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Since its establishment in 1944, Kanto Chemical has continued to develop competitive products in four fields: reagents, electronic materials, clinical diagnostic reagents, and chemical products, under a strict quality control system as a comprehensive reagent manufacturer.