[Analysis Case] Risk Assessment of Nitrosamines in Pharmaceuticals
[Introduction to Ion Chromatography Cases] Measurement of Nitrite and Amines
N-nitrosodimethylamine (NDMA) is an organic compound represented by the chemical formula (CH3)2NNO. NDMA is a known carcinogen found in some fermented foods. The measurement of nitrite ions can be performed using wet chemical analysis, but a representative method in instrumental analysis is ion chromatography (IC). In IC, separation is achieved using an ion exchange column, and detection is carried out using conductivity detection, electrochemical detection, UV detection, or mass spectrometry. Methods using IC typically require little to no sample pretreatment for many pharmaceutical samples, and derivatization of the target components is also unnecessary.
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Thermo Fisher Scientific K.K., the Japanese subsidiary of Thermo Fisher Scientific Incorporated, is a sales company for comprehensive system analysis instruments, bio-related equipment, and research reagents. In Japan, it has bases in Yokohama, Tokyo, Osaka, Fukuoka, and Nagoya, handling various analytical instruments including mass spectrometers, various bio-related equipment, measuring instruments, medical devices, lab software, and research reagents.