Using the desalting tube "Solnac Tube" for LC/MS! Online removal of dodecyl sulfate.
When analyzing highly polar basic compounds using reversed-phase partition chromatography, adding acidic ionic species to the eluent can enhance retention by forming neutral ion pairs through ionic bonding. Sodium dodecyl sulfate, used as an ion-pairing reagent, is non-volatile and can precipitate in the ionization section of the MS, making it difficult to introduce, and it can suppress the ionization of the analytes, thus it cannot be used for online LC/MS measurements. In this case, we used a system with ammonium dodecyl sulfate (ADS) added, using caffeine and thiamine hydrochloride as samples, and removed dodecyl sulfate from the sample solution using a Solnack tube to perform positive ion measurements. For details on the conditions and analysis results, please download the catalog. 【Infusion Conditions】 ■Samples: (1) Caffeine 10 ppm solution, (2) Thiamine hydrochloride 10 ppm solution ■Solvent: CH3CN / H2O = 50 / 50 + 10 mM Ammonium dodecyl sulfate ■Flow rate: 0.1 ml/min *For more details, please refer to the PDF document or feel free to contact us.
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【MS Conditions (Partial)】 ■Device: JEOL JMS-T100LP ■Ionization Method: ESI Pos. ■Needle Voltage: 2000 V ■Orifice 1 Voltage: 50 V ■Desolvation Chamber Temperature: 250 ℃ *For more details, please refer to the PDF document or feel free to contact us.
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For more details, please refer to the PDF document or feel free to contact us.
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Our company develops contract services utilizing our unique high-level technical expertise in imaging mass spectrometry and liquid chromatography mass spectrometry. As a venture originating from Hamamatsu University School of Medicine, we leverage our unique technology related to IMS, cultivated over many years in the Cell Molecular Anatomy course, along with our extensive experience in mass spectrometry, including a Level 5 LC/MS analyst certification, to provide high-quality mass spectrometry data.