Latest information: It is now possible to connect to existing Raman spectrometers. Analysis and evaluation of tablets and capsule formulations have become easier.
A newly developed forward scattering (transmission) unit was connected to an existing Raman spectrometer, and using model formulations, the practicality and usefulness of the forward scattering unit were demonstrated. The forward scattering unit (from Horiba, Kyoto) is connected to the ALL-IN-ONE Raman spectrometer (Marqmetrix, Seattle, USA) via fiber optics. The measurement conditions included a spectral resolution of 6 cm-1, an excitation laser wavelength of 785 nm, a single accumulation, and an exposure time of 3 seconds. The sample is simply placed on the standard sample stage, eliminating the need for sample positioning or height adjustments. The company also provides holders compatible with different dosage forms, including glass containers and powdered samples, in addition to the tablets and capsules used in this study. It should be noted that while this experiment was conducted by connecting the forward scattering unit to the Marqmetrix ALL-IN-ONE for sample measurement, the unit can be connected and used with any Raman spectrometer that has fiber connection ports for the excitation laser and Raman scattered light (for example, Raman spectrometers from Wasatch Photonics).
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basic information
The connection of the forward scattering unit to the fiber connection port of the spectrometer allows for easy measurement of Raman spectra, resulting in high versatility and the expectation of widespread adoption in the market. From the measurement results of the tablets, it has become clear that using forward scattering can reduce the impact of film coating and provide a broader range of component information.
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Applications/Examples of results
Film-coated tablets: Analysis and evaluation of the active ingredient content and crystal polymorphism in capsule formulations.
Detailed information
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Backward scattering and forward scattering: Explanation of Raman spectroscopy.
Company information
Our company supports the establishment of measurement methods, analytical techniques, and testing methods (analytical methods) using Raman spectroscopy, centered on vibrational spectroscopy, which can be utilized in quality control areas such as acceptance testing, from research and development fields like the evaluation of the physical properties of pharmaceutical raw materials and the dispersion state of solid formulation particles. We provide support for the development of analytical conditions, testing method settings, and validation. Please feel free to contact us if you have any requests.