Case study of pharmaceutical analysis using forward scattering (transmission) Raman spectroscopy.
In the analysis of pharmaceutical tablets and capsules, it can be difficult to easily obtain information about the physical state and components of the active pharmaceutical ingredient inside the tablet or capsule due to interference from the tablet coating or capsule material. In this study, commercially available coated drugs and capsules filled with active pharmaceutical ingredients of different raw materials were used as model formulations. By employing forward scattering (transmission) Raman spectroscopy, we demonstrate that it is possible to reduce surface interference caused by the coating of the tablet or capsule and analyze and evaluate the components.
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basic information
By connecting the forward scattering unit to the fiber connection port of the spectrometer, it became easy to measure Raman spectra, resulting in high versatility and expectations for market expansion. From the measurement results of tablets and capsules, it was revealed that using forward scattering can reduce the influence of film coating and provide a broader range of component information. In the future, we would like to advance experiments and research towards new applications, such as applying it to content uniformity tests in formulation studies and evaluating the crystal forms of active ingredients in soft capsules.
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Applications/Examples of results
Analysis of active ingredients in coated tablets and capsule formulations.
Detailed information
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Forward scattering unit and forward scattering (transmission) measurement image.
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Company information
Our company supports the establishment of measurement methods, analytical techniques, and testing methods (analytical methods) using Raman spectroscopy, centered on vibrational spectroscopy, which can be utilized in quality control areas such as acceptance testing, from research and development fields like the evaluation of the physical properties of pharmaceutical raw materials and the dispersion state of solid formulation particles. We provide support for the development of analytical conditions, testing method settings, and validation. Please feel free to contact us if you have any requests.