The technical information magazine The TRC News provides the latest information on analytical techniques that are useful for research and development, solving production troubles, and quality control.
**Abstract** In recent years, research and development have been focused on drug delivery systems (DDS) aimed at reducing side effects of pharmaceuticals and improving their efficacy. Carriers used in DDS include biomaterials such as liposomes, polymer micelles, inorganic nanoparticles, and drug conjugates (e.g., ADCs). Among these, our company is concentrating on establishing analysis and evaluation techniques for liposomes, introducing case studies of liposome analysis primarily using high-difficulty techniques such as TEM (transmission electron microscopy) and AFM (atomic force microscopy). **Table of Contents** 1. Introduction 2. Fundamental technologies of DDS and characteristics of various carriers 3. Case studies of liposome analysis and evaluation 4. Conclusion
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Technical Information Magazine The TRC News "Current Status of Biomaterials Used in DDS Technology and Efforts for Analysis and Evaluation" [Abstract] In recent years, research and development focusing on Drug Delivery Systems (DDS) has been advancing with the aim of reducing side effects of pharmaceuticals and improving their efficacy. Biomaterials such as liposomes, polymer micelles, inorganic nanoparticles, and Drug Conjugates (e.g., ADCs) are cited as carriers used in DDS. Among these, our company is concentrating on establishing analysis and evaluation techniques for liposomes, and we will introduce analysis cases of liposomes, focusing on the challenging techniques of TEM and AFM. [Table of Contents] 1. Introduction 2. Fundamental Technologies of DDS and Characteristics of Various Carriers 3. Analysis and Evaluation Cases of Liposomes 4. Conclusion [Figures and Tables] Figures 1-9, Tables 1-4 Carriers used in DDS, Tumor targeting approaches via DDS DSC measurement results of liposomes, zeta potential measurement results, particle size distribution before and after extrusion treatment, average particle diameter and polydispersity index, cryo-TEM images AFM layers of liposomes (in liquid), elasticity of liposomes (vesicle strength)
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At Toray Research Center, Inc., we provide technical support through analytical techniques and physical property analysis to address various challenges in research and development as well as production fields via contract analysis. Based on our long-standing achievements and extensive experience in analysis and physical property evaluation, we continue to strive to meet the advanced and diverse needs of our customers.
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