1. Ideal for artificial membrane permeability tests without using Caco-2 cells. 2. Good reproducibility and wide applicability. 3. 96-well format.
PermeaPad Plate uses a unique lamination technology to pack a phospholipid membrane with a cellulose film membrane, creating an artificial membrane (PermeaPad). PermeaPad is used in artificial membrane permeability tests for early-stage drug screening. It can be stored at room temperature and does not require any pre-treatment, making it easy to handle. Due to its three-layer structure of <cellulose>-<phospholipid>-<cellulose>, PermeaPad is resistant to solvents and surfactants, allowing for permeability testing. Furthermore, it maintains stable permeability across a wide pH range (pH 1 to 10), making it less susceptible to pH gradients and enabling tests under various conditions. The PermeaPad Plate is in a 96-well plate format. The drugs added to the insert plate (or bottom plate) permeate to the bottom plate (or insert plate), and the concentration changes are analyzed using HPLC or LC-MS. The bottom plate can be set in a standard microplate reader, providing excellent versatility.
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basic information
◆Drug permeability testing using artificial membranes without Caco-2 cells ◆Multi-layer structure of lipids and film using proprietary laminate technology ◆High reproducibility in testing ◆Stable testing over a wide pH range
Price range
P3
Delivery Time
Applications/Examples of results
PAMPA Drug Permeability Test Using Artificial Membrane
Company information
Reprocell Inc. is a company that develops its business primarily in the fields of iPS cell and clinical testing. Even before the invention of iPS cells, we had been accumulating research on ES cells, and by leveraging that technology and extensive experience in iPS cells, we have successfully commercialized world-leading iPS cell products. We also provide research reagents, culture materials, clinical testing services such as cell and biological samples, drug discovery support services, and HLA typing. Please feel free to contact us when you need our services.
