A fully human antibody mouse that ensures the normal development of B cells and directly expresses fully human IgG!
The "CAMouse" is a fully human antibody mouse that directly expresses fully human IgG while ensuring the normal development of B cells in mice. Human immunoglobulin heavy chain and K/λ light chain genes have been introduced, while simultaneously inactivating the endogenous heavy and light chain genes in the mouse. Seventy human immunoglobulin V regions, including 32 VH, 22 VK, and 16 Vλ, have been incorporated, providing a rich diversity of rearrangement. [Technological Advantages] ■ Establishment of efficient transgenic technology for ultra-large genes (>500kb) ■ Development of technology to spatially and temporally control B cell development in the host animal, allowing for the production of fully human IgG all at once. *For more details, please download the PDF or feel free to contact us.
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【Application Examples】 ■ Evaluation of the immune characteristics of CAMouse and its ability to screen for high-affinity antibodies ■ Development of novel fully human antibodies for coronavirus treatment ■ Development of fully human bispecific antibodies targeting GPC3/CD3 *For more details, please download the PDF or feel free to contact us.
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【Success Stories】 ■Biosion ■Syncopation Life Sciences (acquired by CARGO) ■Boostimmune *For more details, please download the PDF or feel free to contact us.
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World Quality Biotech Co., Ltd. responds to the cutting-edge research and development needs in the life sciences field by providing a wide range of laboratory consumables and standard products for genetic analysis. Additionally, we offer development services for fully human antibody drugs using our technology platform (CAMouse) based on fully human antibody mice, aimed at early exploration of fully human antibody drugs for our customers. Our company provides world-class products and services through rigorous quality control, earning customer satisfaction and trust. As the name suggests, World Quality Biotech Co., Ltd. aims to contribute to the advancement of life sciences as a trusted company by providing high-quality products and services at a "low price" and with "rapid distribution" in the life sciences field.