Test for detecting genetic mutations
Our company conducts tests to detect the mutagenicity of chemical substances using bacteria. We expose histidine-requiring Salmonella typhimurium and tryptophan-requiring Escherichia coli to several dose levels (usually more than five). Typically, experiments are conducted under two conditions: in the presence and absence of an exogenous metabolic activation system (S9 mix). A positive result is determined when the number of revertant mutation colonies increases by more than twice compared to the negative control group, and a dose-dependent response is observed. 【Features】 ■ Detection of mutations caused by base substitution or frameshift through the use of several types of bacteria ■ Can be conducted inexpensively and within a short period ■ Required for various application documents *For more details, please download the PDF or feel free to contact us.
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basic information
【Basic Specifications】 ■Test Strains ・Salmonella typhimurium strains: TA1535, TA1537, TA97, TA98, TA100, TA102, etc. ・Escherichia coli: WP2uvrA, WP2uvrA/pKM101, etc. *Select about 5 types according to the purpose. ■Testing and Experiments ・Pre-incubation method, counting of revertant mutation colonies ・As an option, analysis of test substances/dosing solutions, etc. *For more details, please download the PDF or feel free to contact us.
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Our company is engaged in the production of gene knockout mice, providing genetic information to research institutions such as universities and pharmaceutical companies, selling reagents, and conducting non-clinical and clinical trial contracts, as well as pathological diagnosis. Through the development of biological resources from individual organisms to genomes, we provide genetic information for foundational research and in the fields of medicine and healthcare. Please leave the production and sale of knockout mice, gene knockout mice, and antibodies to us.