Describing a method to rescue low-expressing cells and perform efficient APC assays.
The Kv1.3 ion channel regulates the activation of T lymphocytes and controls membrane potential and calcium signaling in immune responses. Dysregulation is associated with autoimmune diseases such as multiple sclerosis, psoriasis, and rheumatoid arthritis. The Kv1.3 channel also plays a role in the proliferation and survival of cancer cells. Therefore, the Kv1.3 channel is considered a promising target for the treatment of both autoimmune diseases and cancer. Efficient ion channel assays require consistent, robust, and functional membrane expression. Using a low-expressing Kv1.3 cell line, we classified cells based on Kv1.3 expression using the Tyto cell sorter (from Miltenyi Biotec), significantly improving the success rate of QPatch assays. *For more detailed information, please refer to the related links. Feel free to contact us for more details.*
Inquire About This Product
basic information
*You can view the detailed content of the article through the related link. For more information, please feel free to contact us.*
Price range
Delivery Time
Applications/Examples of results
*You can view the detailed content of the article through the related links. For more information, please feel free to contact us.*
catalog（3）
Download All Catalogs
News about this product（1）
Company information
Sophion Bioscience was founded by a passionate group of electrophysiologists with a common goal of providing objective patch clamp results quickly and accurately, independent of the experimenter's skill. We have grown from a small startup in Denmark to a global company, but our passion and commitment to providing high-performance patch clamp solutions remain unchanged. Through exceptional technical service and application support, we back our customers in achieving their goals. Additionally, with the continuous development of the QPatch and Qube platforms, we ensure uncompromising data quality in a user-friendly environment, from assay setup to data analysis.