A revolutionary gold grid enables stable imaging! With a high-density hexagonal design and ultra-small holes, it supports the generation of uniformly thick ice.
HexAuFoil samples support improves every image! CryoEM inherently has issues with data loss caused by particle movement during imaging, which leads to a decrease in mapping quality. While data processing can mitigate this data loss, advanced sample processing techniques are required. To address these issues, we propose a solution using the new cryoEM grid "HexAuFoil," which has been launched by Quantifoil, a group company of SPT Labtech.
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basic information
HexAuFoil is composed of gold foil with holes arranged on a hexagonal gold mesh grid. The hexagons of the grid are approximately 50 μm in size, and the outer shell diameter is about 10-12 μm. The gold foil has holes with a diameter of 290 nm arranged in a hexagonal pattern, with a spacing of 310 nm between the holes, forming a repeating structure of 600 nm. The ultra-small pore gold support reduces particle movement to below the angstrom level. The small pore size provides additional stability to the thin ice layer supporting the sample, reducing or eliminating ice warping due to cryo-cooling. The position of the particles stabilizes, allowing for mapping to be estimated to zero electron loss before radiation damage occurs. Efforts are being made to reduce particle movement while improving the throughput of automated cryoEM without compromising map quality, incorporating features such as maximum pore density.
Price range
P3
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Applications/Examples of results
Grid for cryoEM
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Company information
We aim to embed our unique technology and deep understanding of applications into each product, providing researchers with new options to accelerate their research. In addition to user-friendly specifications and highly robust systems, the establishment of our Japan branch has enabled us to offer rapid engineering support. We specialize in applications that require nanoliter-scale dispensing, reducing sample and time costs: - Miniaturization/automation of various assays - Miniaturization/automation of PCR, qPCR, and NGS library preparation in the genomics field - Miniaturization/automation in the field of protein crystallization - Automated management of sample vials We have experienced representatives and dedicated application staff in the country. We look forward to your inquiries and demo requests.