[Case Study of Crystallization Device] Confirmation of Crystal Form Transition by Crystalline

A case where the timing of crystal form transition was confirmed, and it was verified whether conditions could be established to easily collect the desired crystal form!

We would like to introduce a case study on the utilization of the crystallization device "Crystalline." Using this device (manufactured by Technobis), which has a camera function, we confirmed the timing of the transition between crystal forms and whether we could easily set conditions to recover the desired crystal form. In cases like carbamazepine, where the crystal form transitions rapidly, it is necessary to accurately grasp the timing of crystal generation and the transition of crystal forms in order to obtain the crystal form before the transition. By using the camera function of this device, we can observe the situation inside the vial and easily confirm the desired timing. [Test] - Carbamazepine yields needle-like Type II crystals through rapid cooling, which then transition to block-like Type III crystals. - Measurements were conducted using the following program to confirm the timing of Type II crystal generation and the transition to Type III crystals: - Raise the solution temperature to 70°C and confirm that carbamazepine is completely dissolved. - Cool to 20°C at -20°C/min. - Hold at 20°C for 4 hours. *For more details, please download the PDF or feel free to contact us.

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