[Application Note] A cost comparison between TOC measurement and HPLC in cleaning validation was conducted!
Cleaning validation is a very important process in the pharmaceutical industry. Various analytical methods are used to ensure that manufacturing equipment is properly cleaned. Among these, TOC analyzers and HPLC are widely used as representative methods. Here, we conducted a cost comparison of TOC analyzers and HPLC from various perspectives (initial costs, maintenance costs, and labor costs).
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- Initial Cost When comparing the initial costs of a TOC analyzer and HPLC, HPLC is more expensive due to its complex system. - Maintenance Cost The annual maintenance cost of HPLC includes the price of parts and service costs, making it more expensive than a TOC analyzer. - Running Cost The annual running cost of a TOC analyzer, when calculated including consumables, reagents, and labor costs, is cheaper than that of HPLC. - Labor Cost The operation and data analysis of HPLC are more complex than those of a TOC analyzer, requiring a higher level of skill, which results in higher labor costs. - Total Cost The TOC analyzer offers better cost-effectiveness in all aspects—initial cost, maintenance cost, and running cost—compared to HPLC. - ROI (Return on Investment) Due to cost reductions from implementing a TOC analyzer, it is possible to recover costs in less than three years, and depending on the operational method, cost recovery may even be achievable in the first year. For more details, please refer to the application note.
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Cleaning validation of pharmaceuticals
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Since our establishment in 1967, we have been dedicated to the development and dissemination of water quality measurement devices that anyone can use quickly, easily, and with high precision. In today's world, where the effective use of water, a limited resource, is required alongside environmental conservation, we aim to be a total solution provider that responds to all water environments by utilizing our water quality measurement devices, technology, and services. Furthermore, leveraging the latest technology and years of know-how, we are committed to delivering user-friendly and reliable water quality measurement devices more affordably, quickly, and widely.