Evaluation of the effects of ultraviolet rays and chemical mutagens using microorganisms and plants.
Life (Saitama University Research Seed Collection 2025-25 p.121)
Keywords: mutagen, ultraviolet light, radiation, DNA repair, Escherichia coli, Aspergillus oryzae, Arabidopsis thaliana
DNA, which carries the genetic information of living organisms, is exposed to various DNA-damaging factors. DNA damage can induce genetic mutations, leading to cancer, genetic diseases, and cellular aging. To protect themselves from these threats, organisms have acquired DNA damage repair mechanisms. This mechanism is present in almost all living organisms on Earth, from E. coli to plants and humans, and each organism builds a DNA repair system suitable for its survival strategy. I am working to elucidate the full extent of the DNA damage repair mechanisms possessed by non-human organisms by conducting basic research on DNA damage repair, mutation induction, and cellular aging using higher plants and microorganisms. In the future, I hope to apply the insights gained from this basic research to promote the growth of useful organisms and reduce diseases caused by pathogenic microorganisms.
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Ryohei Yoshihara, Assistant Professor Graduate School of Science and Technology, Department of Life Sciences, Field of Biological Control 【Recent Research Themes】 ● Elucidation of the mitochondrial DNA maintenance mechanism in filamentous fungi ● Analysis of the DNA double-strand break repair mechanism in higher plants
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【Appeal Points to Industry】 ● Evaluation of toxicity to microorganisms and plants caused by ultraviolet rays and chemical mutagens ● Various analyses using genetic engineering-related equipment 【Examples of Practical Use, Applications, and Utilization】 ● Evaluation of the sterilization effect of a sterilization unit built into medical devices using Escherichia coli
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Plants that are UV-sensitive due to the absence of DNA repair genes.
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The Saitama University Open Innovation Center is a center that functions as a liaison office for industry-academia-government collaboration. It consists of three departments: the Industry-Academia-Government Collaboration Department, the Intellectual Property Department, and the Startup Support Department, each staffed with coordinators well-versed in various fields. The center's activities include solving technical challenges in companies, supporting the implementation of joint research, and conducting technology transfer aimed at introducing and utilizing Saitama University's intellectual property.