Exploring the function of cell membranes through the movement of lipids!
Life (Saitama University Research Seed Collection 2025-25 p.123)
Keywords: Cell membrane, biophysical chemistry, fluorescence spectroscopy measurement, fluorescence correlation spectroscopy, lipid bilayer.
The smallest structural unit of living organisms is the cell, which is covered by a cell membrane primarily composed of a lipid bilayer. This cell membrane functions as a barrier that separates the internal environment of the cell from the outside, while also contributing to the maintenance of life by allowing the uptake of molecules from the external environment as needed. In the special physiological functions of this cell membrane, the physical properties of the lipid bilayer, particularly its dynamics, are very important, and we believe that understanding the movement of lipids within the lipid bilayer will deepen our understanding of the cell membrane. In our laboratory, we are developing and applying new fluorescence spectroscopy methods to precisely analyze the movement of lipids within the lipid bilayer. We are conducting research daily with the aim of understanding the extraordinary functions of living organisms from the movements of small molecules that are invisible to the naked eye.
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Takuhira Otosu, Associate Professor Graduate School of Science and Technology, Department of Materials Science, Fundamental Materials Area 【Recent Research Themes】 ● Detection of microsecond dynamics of proteins ● Development of new measurement devices utilizing light interference ● Measurement of local pH on protein surfaces
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【Appeal Points to the Industry】 ● Quantitative analysis of the physical properties of lipid bilayers ● Analysis of the interactions between membrane-bound proteins and lipid bilayers ● Individual measurement of lipid dynamics within the two monolayers that make up the lipid bilayer ● Construction of microscopy systems tailored to specific needs 【Examples of Practical Use, Applications, and Utilization】 ● Research on the interaction between amyloid-forming proteins and cell membranes ● Detection of functional domains that transiently form within cell membranes ● Quantification of the impact of the cytoskeleton on lipid dynamics
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The Saitama University Open Innovation Center is a center that functions as a liaison office for industry-academia-government collaboration. It consists of three departments: the Industry-Academia-Government Collaboration Department, the Intellectual Property Department, and the Startup Support Department, each staffed with coordinators well-versed in various fields. The center's activities include solving technical challenges in companies, supporting the implementation of joint research, and conducting technology transfer aimed at introducing and utilizing Saitama University's intellectual property.