Create molecules that color sugar.
Life (Saitama University Research Seed Collection 2025-25 p.126)
Keywords: analytical reagents, molecular recognition, supramolecular chemistry, metal complexes, nanoparticles, luminescence, dyes
Various types of sugars exist within living organisms. Each of these plays an essential role in maintaining life and is constantly circulating within the body. Therefore, an imbalance of sugars in the body directly leads to serious diseases that threaten us today (e.g., diabetes). In other words, the development of technology to measure sugar levels is crucial for the early detection of bodily disorders. To develop such technology, I am designing "analytical reagents," which are molecules that glow when they bind to sugars. In my research, I am developing analytical reagents with a simple structure and excellent detection capabilities by using various frameworks (organic dyes, metal complexes, supramolecular complexes, nanoparticles, etc.) as a foundation (Figure 1). So far, I have successfully developed a supramolecular complex-type analytical reagent that specifically fluoresces for D-glucose (blood sugar) among the numerous sugars (Figure 2). I believe that this technology will lead to the development of a diagnostic system for the early detection of diabetes.
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Yota Suzuki, Assistant Professor Graduate School of Science and Technology, Department of Materials Science, Fundamental Materials Area 【Recent Research Themes】 ● Development of analytical reagents to distinguish molecular enantiomers ● Development of detection reagents for ions present in the environment ● Development of molecules to identify the polarity of solvents ● Development of molecules to differentiate types of sugars using light
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【Appeal Points to the Industry】 ● Development of a simple analysis system that can be used anywhere by anyone ● Development of analytical reagents with simple structures that do not require multi-step organic synthesis operations ● Patent applied for (Application No. 2022-129691) 【Examples of Practical Use, Applications, and Utilization】 ● Development of an analytical reagent that fluoresces D-glucose ● Development of an analytical reagent whose solution color changes upon binding with sugars ● Development of an analytical reagent that fluoresces adenosine triphosphate
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Supermolecular complexes that illuminate D-glucoses.
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The Saitama University Open Innovation Center is a center that functions as a liaison office for industry-academia-government collaboration. It consists of three departments: the Industry-Academia-Government Collaboration Department, the Intellectual Property Department, and the Startup Support Department, each staffed with coordinators well-versed in various fields. The center's activities include solving technical challenges in companies, supporting the implementation of joint research, and conducting technology transfer aimed at introducing and utilizing Saitama University's intellectual property.